Behavioural effects in mice of subchronic chlordiazepoxide, maprotiline and fluvoxamine. II. The elevated plus-maze

Pharmacology, Biochemistry, and Behavior
R J RodgersJ E Jackson

Abstract

In view of apparent commonalities in the aetiology, symptomatology, and pharmacotherapy of anxiety and depressive disorders, the present study compares the effects of the benzodiazepine, chlordiazepoxide (1.0-8.0 mg/kg), the selective noradrenaline (NA) reuptake inhibitor, maprotiline (0.5-10.0 mg/kg), and the serotonin (5-HT)-selective reuptake inhibitor, fluvoxamine (2.0-8.0 mg/kg), on the behaviour of mice in the elevated plus-maze test of anxiety. To more accurately reflect the clinical situation, subjects were treated daily for 21 days prior to testing, and comprehensive behavioural profiles were obtained through the application of an ethological scoring technique. Results show that subchronic treatment with chlordiazepoxide produced clear anxiolytic-like effects at the highest dose tested, coupled with an inhibition of risk assessment over the entire dose range. With the exception of risk assessment measures, anxiolytic-like effects were also seen with a low dose (0.5 mg/kg) of maprotiline: these effects were lost at higher doses. In contrast to these data, fluvoxamine produced minimal behavioural change under present test conditions. Findings are discussed in relation to the relative efficacy of selective monoamine. reup...Continue Reading

References

Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·D Nutt, C Lawson
Jul 1, 1991·Neuropeptides·B CostallG N Woodruff
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·R Young, D N Johnson
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·J C Pecknold, L Luthe
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·E S Onaivi, B R Martin
Mar 1, 1989·Pharmacology, Biochemistry, and Behavior·B CostallD M Tomkins
Mar 1, 1986·The Journal of Nervous and Mental Disease·J Reich
Jan 1, 1987·Psychopharmacology·R G Lister
Jan 1, 1988·Psychopharmacology·S R BodnoffM J Meaney
Jan 1, 1986·New Directions for Mental Health Services·J Reich
Nov 1, 1980·Comprehensive Psychiatry·D F Klein
Mar 1, 1995·International Clinical Psychopharmacology·M J FilteauA Blanchard
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·A P CruzF G Graeff
Oct 1, 1994·Pharmacology, Biochemistry, and Behavior·S LightowlerI F Tulloch
Jan 1, 1994·Psychopharmacology·S E FileP S Mabbutt
Jan 1, 1993·Psychopharmacology·R Trullas, P Skolnick
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·D TreitC Royan
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·R J Rodgers, N J Johnson
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·R J RodgersL H Stephenson
May 1, 1997·Pharmacology, Biochemistry, and Behavior·M G CutlerJ E Jackson

❮ Previous
Next ❯

Citations

Mar 10, 2001·Physiology & Behavior·A HolmesR J Rodgers
May 1, 1997·Pharmacology, Biochemistry, and Behavior·M G CutlerJ E Jackson
Mar 9, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B OlivierW Soudijn
May 2, 2009·Behavioural Pharmacology·Gislaine G PelosiFernando M A Corrêa
Aug 23, 2008·Neurotoxicology and Teratology·M Daza-LosadaJ Miñarro
Feb 27, 2007·The Veterinary Journal·Frauke OhlF Josef van der Staay
Jun 20, 2003·The European Journal of Neuroscience·John F CryanHerman van Der Putten
Jun 10, 2014·Physiology & Behavior·A Ennaceur
Jan 9, 2007·Brain Research Bulletin·Josefina EstellesJosé Miñarro
Oct 4, 2007·Basic & Clinical Pharmacology & Toxicology·Bent H Hellum, Odd Georg Nilsen
May 3, 2019·Psychopharmacology·M Carmen Blanco-GandiaMarta Rodríguez-Arias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.