Behavioural outcome in twin-twin transfusion syndrome survivors treated with laser surgery

Archives of Disease in Childhood. Fetal and Neonatal Edition
Fieke L BrandsmaJeanine M M Van Klink

Abstract

Evaluate the incidence of and risk factors for behavioural problems in twin-twin transfusion syndrome (TTTS) survivors treated with fetoscopic laser coagulation. Observational cohort study. National referral center for fetal therapy, Leiden University Medical Center, The Netherlands. Behavioural outcome was assessed in 417 TTTS survivors, at the age of 2 years. Parents completed the Child Behavior Checklist for their twins. Antenatal, neonatal and follow-up data including Bayley III and a neurological exam were recorded from the medical database. The incidence of and risk factors for behavioural problems. 332 twin pregnancies (664 fetuses) were treated with fetoscopic laser for TTTS between 2008 and 2015. For 517 children eligible for follow-up, 417 (81%) Child Behavior Checklist questionnaires were completed. The study group was born at a mean gestational age of 32.8 weeks±3.2. Total behavioural problems within the borderline to clinical range were reported in 8% (95% CI 5.9 to 11.2) of survivors, compared with 10% in the general Dutch population (p=0.12). No difference between donors and recipients was detected (p=0.84). Internalising and externalising problems were reported in 9.4% (95% CI 6.9 to 12.6) and 11.5% (95% CI 8.8 ...Continue Reading

References

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Citations

Aug 29, 2020·Journal of Developmental and Behavioral Pediatrics : JDBP·Hikmat R ChmaitDouglas L Vanderbilt
Sep 11, 2021·The Journal of Pediatrics·Patricia J C KnijnenburgJeanine M M van Klink

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