PMID: 7892028Nov 1, 1994Paper

Behavioural pain-related disorders and contribution of the saphenous nerve in crush and chronic constriction injury of the rat sciatic nerve

Pain
N AttalG Guilbaud

Abstract

This study evaluated the pain-related behaviours induced by 2 models of peripheral sciatic nerve injuries in the rat: transient nerve crush and chronic constriction injury (CCI). Various lesions of the saphenous nerve were performed in order to investigate the role of saphenous innervation in behavioural disorders induced by these nerve injuries. Behavioural testing included assessment of responses to phasic stimulation (mechanical and thermal) and observation of 'spontaneous' pain-related behaviour. Results confirmed that the model of CCI induces marked and prolonged phasic and spontaneous pain-related disorders (up to week 7). Rats with crush injury exhibited moderate and transient hyperalgesia and allodynia to mechanical and thermal stimulation on the lesioned side (with a maximum at day 3 and a recovery by week 1). Section plus ligation of the ipsilateral saphenous nerve on the day of surgery prevented nociceptive behaviours and induced persistent mechanical and thermal anaesthesia or hypoesthesia of the lesioned paw in both models (lasting up to 3-4 weeks). Section without ligation of the saphenous nerve induced comparable results in rats with sciatic crush, but did not significantly modify nociceptive behaviours in rats w...Continue Reading

References

May 1, 1979·The Journal of Comparative Neurology·M DevorP D Wall
Sep 30, 1991·Neuroscience Letters·S M CarltonR E Coggeshall
Jul 1, 1991·British Medical Bulletin·P D Wall
Dec 9, 1991·Neuroscience Letters·J A Vallin, W S Kingery

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Citations

Nov 18, 1998·Annals of Neurology·A L OaklanderR A Meyer
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Linda S Sorkin, Tony L Yaksh
Jan 1, 1997·European Journal of Pain : EJP·P ShortlandC Molander
Jul 20, 2002·Regional Anesthesia and Pain Medicine·Quinn Hogan
Jan 10, 2008·Neuro-degenerative Diseases·B FrickerF René
Nov 24, 2006·Anesthesiology·Ratan K BanikTimothy J Brennan
Dec 19, 2012·The Spine Journal : Official Journal of the North American Spine Society·Changsheng HuangQulian Guo
May 4, 2004·Annals of Neurology·Anne Louise Oaklander, Jennifer M Brown
Feb 11, 2015·Neuroscience and Biobehavioral Reviews·Charles J Vierck, Robert P Yezierski
Sep 16, 2014·Frontiers in Neuroscience·Monica NorciniEsperanza Recio-Pinto
May 18, 2017·Pain·Pedram HamrahAnne Louise Oaklander

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