Behavioural response to pharmacologic manipulation of serotonin receptors in the genetically dystonic hamster

Pharmacology, Biochemistry, and Behavior
A Richter, W Löscher

Abstract

The genetically dystonic (dtsz) hamster is an autosomal recessive mutant that shares several features with paroxysmal dystonia, i.e., a subcategory of inherited idiopathic dystonia in humans. Because the serotonin (5-HT) system has been suggested to be involved in dystonia, we examined the functional responsiveness of the 5-HT system in dystonic hamsters by administering various 5-HT agonists and antagonists selective for different receptor subtypes and observing the effects on dystonic attacks as well as the behavioural responses associated with drug administration. Paradoxically, marked prodystonic effects (i.e., increased severity and/or decreased latency of dystonic attacks) were seen with both the selective 5-HT1A receptor agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT) and the selective and "silent" 5-HT1A receptor antagonist, N-tert-butyl-3[4-(2-methoxyphenyl)piperazin-1-yl]-2- phenylpropionamide [(+)-WAY-100135], whereas other 5-HT1A receptor antagonists, i.e., methyl 4[4-(4-[1,1,3-trioxo-2H-1,2-benzoiosothiazol-2-yl]butyl)-1- piperazinyl]1-H-indole-2-carboxylate (SDZ 216-525) and N1-bromoacetyl-N8-3'-(4-indolyloxy)-2'-hydroxypropyl-(Z)-1,8- diamino-p-methane (pindobind-5-HT1A) did not alter dystonia to any co...Continue Reading

References

Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·L M LiauS J Peroutka
Jul 23, 1991·European Journal of Pharmacology·S Benloucif, M P Galloway
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·R A Glennon, M Dukat
Apr 1, 1990·The Journal of Pharmacy and Pharmacology·S AhleniusA Wijkström
Feb 24, 1990·BMJ : British Medical Journal
Aug 1, 1990·British Journal of Pharmacology·L I BackusD G Grahame-Smith
Oct 2, 1990·European Journal of Pharmacology·H H BerendsenA M Van Delft
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·V L MichelaJ F Lorden
Feb 14, 1989·European Journal of Pharmacology·J Arnt, J Hyttel
Sep 22, 1989·European Journal of Pharmacology·H DabiréH Schmitt
Oct 24, 1989·European Journal of Pharmacology·H DabiréH Schmitt
Jan 1, 1989·Movement Disorders : Official Journal of the Movement Disorder Society·S Fahn
Jan 1, 1989·Movement Disorders : Official Journal of the Movement Disorder Society·W LöscherW B Iturrian
Feb 16, 1988·European Journal of Pharmacology·W D BowenJ F Lorden
Oct 1, 1988·The International Journal of Neuroscience·R Sandyk, H Fisher
Sep 1, 1993·Trends in Neurosciences·B L Jacobs, C A Fornal
Mar 1, 1994·International Clinical Psychopharmacology·B E Leonard
Dec 1, 1993·Trends in Pharmacological Sciences·A FletcherC T Dourish
Jun 24, 1993·European Journal of Pharmacology·A FletcherY Reilly
Feb 9, 1993·European Journal of Pharmacology·A RichterP A Löschmann
Feb 15, 1993·European Journal of Pharmacology·P SchoeffterD Hoyer

❮ Previous
Next ❯

Citations

Apr 30, 1998·Progress in Neurobiology·A Richter, W Löscher
Mar 14, 2007·European Journal of Pharmacology·Svenja Esther Sander, Angelika Richter
Apr 14, 2016·Neuroscience and Biobehavioral Reviews·M SmitM A Tijssen
Mar 20, 2020·Prague Medical Report·Jamir Pitton Rissardo, Ana Letícia Fornari Caprara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.