PMID: 11914112Mar 27, 2002Paper

Behavioural significance of prolactin signalling in the central nervous system during pregnancy and lactation

Reproduction : the Official Journal of the Society for the Study of Fertility
David R Grattan

Abstract

The role of prolactin in the regulation of mammary gland development and function during pregnancy and lactation is well established. However, in addition, prolactin appears to have a much wider role in the physiology of lactation. There is widespread expression of prolactin receptors in the hypothalamus during lactation, indicative of a multi-faceted role for prolactin in regulating hypothalamic function. During pregnancy and lactation, the maternal brain undergoes structural and functional modification, allowing the establishment of appropriate behaviour to feed and nurture the offspring, to adjust to the nutritional and metabolic demands of milk production, and to maintain appropriate hormone secretion to allow milk synthesis, secretion and ejection. The coordination of such a range of neurobiological and neuroendocrine adaptations requires an endocrine signalling mechanism, capable of communicating the reproductive state to the brain. Evidence indicates that prolactin is part of this mechanism.

Citations

May 29, 2013·Behavioural Brain Research·Luz TornerEsther Olvera-Cortés
Nov 12, 2013·Neuropeptides·Benjamin Nephew, Chris Murgatroyd
Feb 21, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Supaporn PuntheeranurakKarl Kunzelmann
Jan 1, 2010·Reproductive Biology and Endocrinology : RB&E·Ping ZhangGong Ju
Dec 7, 2007·Endocrine Reviews·Nira Ben-JonathanElizabeth W LaPensee
Jun 3, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Thaísa M SandiniHelenice de S Spinosa
Feb 6, 2004·Toxicology and Applied Pharmacology·Paul S CookeRobert E Chapin
Mar 24, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Raffaele CapassoFrancesca Borrelli
May 18, 2007·Neurobiology of Learning and Memory·Cheryl A FryeAlicia A Walf
Jun 9, 2007·Physiology & Behavior·David R GrattanRachael A Augustine
Feb 13, 2008·Journal of Neuroendocrinology·David R GrattanStephen J Bunn
Jul 8, 2008·Journal of Neuroendocrinology·D R Grattan, I C Kokay
May 2, 2007·Australian Veterinary Journal·J S KopinskiS-A Murray
Apr 17, 2007·The European Journal of Neuroscience·Nina DonnerInga D Neumann
Sep 29, 2011·The Journal of Comparative Neurology·Tony J SapsfordDavid R Grattan
Jan 25, 2011·Journal of Neuroscience Research·Pengfei GaoKenji Watanabe
Nov 18, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pier Giorgio Crosignani
Sep 6, 2005·Hormones and Behavior·Karin J BodensteinerLyndsey A Hamula
Sep 6, 2013·Hormones and Behavior·Lindsay M Carini, Benjamin C Nephew
Oct 5, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wendy Saltzman, Dario Maestripieri
Sep 18, 2012·Frontiers in Neuroendocrinology·P R Le TissierP Mollard
Jun 3, 2016·Integrative and Comparative Biology·Theodore GarlandWendy Saltzman
Jun 30, 2016·Journal of Neuropsychology·Hannah RosenbergR Frederick Westbrook
Dec 30, 2016·Neuropsychological Rehabilitation·Hannah RosenbergReginald Frederick Westbrook
Dec 13, 2007·Nature Reviews. Neuroscience·Paula J Brunton, John A Russell
Feb 25, 2003·Nature Neuroscience·Kazuhito TomizawaHideki Matsui
Apr 19, 2018·Anais Da Academia Brasileira De Ciências·Rafael G DE Souza, Diogenes A Campos
Apr 22, 2005·British Journal of Haematology·Claire Harrison
Jul 23, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A MouihateQ J Pittman
Oct 16, 2014·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Abdramane Bassiahi SouraYacouba Compaore
Feb 26, 2019·Journal of Neuroendocrinology·Rachael A AugustineSharon R Ladyman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.