Behavioural stress facilitates the induction of long-term depression in the hippocampus

Nature
L XuM J Rowan

Abstract

The induction of activity-dependent persistent increases in synaptic efficacy, such as long-term potentiation (LTP), is inhibited by behavioural stress. The question arises whether stress also affects the ability to induce persistent decreases in synaptic efficacy, such as long-term depression (LTD). We now report that the induction of stable homosynaptic LTD in the CA1 area of the hippocampus of awake adult rats is facilitated, rather than inhibited, by exposure to mild naturalistic stress. The same stress blocked the induction of LTP. The effects of such stress were short lasting: acclimatization to, or removal from, the conditions that facilitated LTD induction led to a rapid loss of the ability to elicit this form of plasticity. The time window in which LTD could be reliably elicited was prolonged by inducing anaesthesia immediately after the stress. These data reveal that even brief exposure to mild stress can produce a striking shift in the susceptibility to synaptic plasticity in the awake animal.

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Citations

Sep 24, 1999·Journal of Neuroscience Research·C Hölscher
Nov 19, 2003·Hippocampus·Raby Bouras, C Andrew Chapman
Aug 31, 2012·European Archives of Psychiatry and Clinical Neuroscience·Claus NormannLukas Frase
Jun 7, 2008·Neuromolecular Medicine·Brian R ChristieAndrea K Titterness
Dec 13, 2003·Neurobiology of Learning and Memory·Gabriel K HuiNorman M Weinberger
Mar 24, 2005·Progress in Neurobiology·Peter J MorganeDavid J Mokler
Dec 9, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Benno Roozendaal
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Marcela B EcheverryElaine A Del Bel
Jan 9, 1999·Trends in Neurosciences·J J Kim, K S Yoon
Sep 11, 1999·Trends in Neurosciences·E R de KloetM Joëls
Apr 22, 1999·Behavioural Brain Research·C Hölscher
Mar 10, 2001·Progress in Neurobiology·S M O'MaraJ Gigg
Aug 31, 2001·Progress in Neurobiology·N Kemp, Z I Bashir
Feb 13, 1999·Progress in Neurobiology·M J Millan
Aug 6, 2002·Neuroscience Letters·Kwang-Sik LeeChang-Ju Kim
May 25, 1999·Neuroscience·D R Chialvo, P Bak
Feb 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wen-Jie RenXian-Guo Liu
Mar 20, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chien-Chung ChenKuei-Sen Hsu
May 18, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giorgi BatsikadzeMichael A Nitsche
Jul 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven DuffyJohn C Roder
Jul 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amelia Gallitano-MendelJeffrey Milbrandt
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher Pittenger, Ronald S Duman

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