Behavioural toxicity of medicinal drugs. Practical consequences, incidence, management and avoidance

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
J G Ramaekers

Abstract

Behavioural toxicity is relatively common among medicinal drug users and evidence shows that drugs frequently produce adverse effects that prevent their users from performing everyday operations in a normal manner. Epidemiological research generally indicates that the use of sedative drugs is associated with an increased risk of becoming involved in injurious accidents. Empirical studies have also demonstrated adverse effects of sedative drugs on the performance of healthy volunteers and patients in laboratory tests designed to measure psychomotor and cognitive function, and in real life-tests measuring on-the-road driving performance. Empirical studies also indicate that behavioural toxicity can vary widely between individual drugs depending on differences in dose, dosing regimen, duration of treatment, pharmacokinetics or mechanisms of actions. Besides sedation, other CNS adverse effects such as aggression, paranoia, social withdrawal or lack of motivation may disrupt or prevent the initiation of normal performance, thus imposing a burden on the ability of the patients to function in a normal manner. Emotional disturbances are rare as indicated by the small number of case reports that mention their existence. Yet theses distu...Continue Reading

Citations

Nov 15, 2011·Psychopharmacology·Ries SimonsGisela Skopp
Aug 17, 2011·Prevention Science : the Official Journal of the Society for Prevention Research·Ching-Cheng HouKow-Tong Chen
Sep 25, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William D FinkleKenneth L Melmon
Apr 11, 2006·Nature Reviews. Drug Discovery·David BorsookRichard Hargreaves
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Angela F CaveneyGeorge M Haig
Apr 20, 2004·Accident; Analysis and Prevention·K L L MovigA C G Egberts
Apr 28, 2009·Accident; Analysis and Prevention·Patarawan WoratanaratTongtavuch Anukarahanonta
Apr 8, 2020·Drugs & Therapy Perspectives : for Rational Drug Selection and Use·Negar GolchinAlexis Horace
Feb 16, 2021·Neuroscience and Biobehavioral Reviews·Lilian KloftHenry Otgaar

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