Behçet's disease: comparing 3 decades of treatment response at the National Eye Institute.

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Leila I KumpGrace A Levy-Clarke

Abstract

The goal of the present study was to analyze differences in response to the treatment of ocular Behçet's disease (BD) in the 1960s, 1980s, and 1990s. Medical records of 120 patients with uveitis due to BD followed at the National Eye Institute, National Institutes of Health, from 1962 to 2004, were reviewed. The patients were categorized into 3 groups according to the time of follow-up: the first group was followed from 1962 until 1972, the second group from 1983 until 1992, and the third group from 1992 through 2004. Snellen visual acuity was converted to logMAR values. The range of values for inflammation was 0.5 (trace), 1 (mild), 2 (moderate), and 3 (severe). There were 45 patients (89 affected eyes) in the 1960s group, 26 patients (52 eyes) in the 1980s group, and 49 patients (94 eyes) in the most recent group. Statistical analysis showed that the mean logMAR score decreased with each decade. Mean visual acuity in the 1990s group was significantly better than in the previous decades (p < 0.001 for the 1960s group and p = 0.019 for the 1980s). The mean inflammation score was significantly higher in the 1960s than in the subsequent decades (p < 0.001 both for the 1980s and for the 1990s). BD is a severe, blinding disorder. T...Continue Reading

References

Oct 1, 1977·Archives of Ophthalmology·D M ColvardJ D O'Duffy
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·L S Atmaca
Aug 1, 1986·The British Journal of Ophthalmology·D Benezra, E Cohen
Oct 1, 1970·Archives of Ophthalmology·J G Mamo
Feb 1, 1995·Ophthalmology·M SakamotoY Nose
May 21, 2003·International Journal of Dermatology·Umit TursenAyse Boyvat
Mar 31, 2004·Ophthalmology·Atsushi YoshidaMakoto Araie
Sep 15, 2004·American Journal of Ophthalmology·Ilknur Tugal-TutkunMeri Urgancioglu

❮ Previous
Next ❯

Citations

Jan 31, 2014·Orphanet Journal of Rare Diseases·Robert J BarryPhillip I Murray
Jan 5, 2016·Ocular Immunology and Inflammation·Massimo AccorintiPaola Pivetti-Pezzi
Feb 13, 2016·Auto- Immunity Highlights·Mohamad J ZeidanPatrice Cacoub
Nov 12, 2015·BioMed Research International·Michele FigusMarco Nardi
Dec 17, 2009·Ophthalmology·Ali A ZaidiUNKNOWN Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study
Feb 4, 2014·The Journal of Rheumatology·Gulen HatemiHasan Yazici
Feb 27, 2019·Ocular Immunology and Inflammation·Hisae NakaharaMakoto Aihara
Nov 30, 2011·International Ophthalmology Clinics·Seth M Pantanelli, Yousuf M Khalifa
Sep 10, 2020·Clinical, Cosmetic and Investigational Dermatology·Preeyachat LimtongPintip Ngamjanyaporn
Jan 1, 2014·Journal of Immunology Research·Olfat G ShakerAhmed A Heikal
Feb 10, 2021·Modern Rheumatology·Aida Malek MahdaviMehrzad Hajialilo
Jun 24, 2021·Annals of Medicine and Surgery·Ben Abdesslem NadiaKrifa Fethi
Nov 3, 2021·Vestnik oftalmologii·I Yu Razumova, A A Godzenko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.