PMID: 9448239Mar 14, 1998Paper

Behind the scenes of functional brain imaging: a historical and physiological perspective

Proceedings of the National Academy of Sciences of the United States of America
M E Raichle

Abstract

At the forefront of cognitive neuroscience research in normal humans are the new techniques of functional brain imaging: positron emission tomography and magnetic resonance imaging. The signal used by positron emission tomography is based on the fact that changes in the cellular activity of the brain of normal, awake humans and laboratory animals are accompanied almost invariably by changes in local blood flow. This robust, empirical relationship has fascinated scientists for well over a hundred years. Because the changes in blood flow are accompanied by lesser changes in oxygen consumption, local changes in brain oxygen content occur at the sites of activation and provide the basis for the signal used by magnetic resonance imaging. The biological basis for these signals is now an area of intense research stimulated by the interest in these tools for cognitive neuroscience research.

References

Oct 1, 1978·Scientific American·N A LassenE Skinhøj
Jan 1, 1975·Radiology·M M Ter-PogossianN A Mullani
Aug 15, 1992·The Journal of Comparative Neurology·C A Harley, C H Bielajew
Sep 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·J FrahmW Hänicke
Jun 1, 1992·Stroke; a Journal of Cerebral Circulation·H YamauchiJ Kimura
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J L Lear, R K Kasliwal
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G M KnudsenM M Hertz
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J PrichardR Shulman
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jan 1, 1989·Experimental Brain Research·O CreutzfeldtE Lettich
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M UekiK A Hossmann
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P T Fox, M E Raichle
Dec 1, 1973·The British Journal of Radiology·G N Hounsfield
Jan 1, 1969·Acta Psychologica·F C Donders
Mar 25, 1983·Science·P W Hochachka, T P Mommsen
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P YarowskyL Sokoloff
Aug 1, 1983·Annals of Neurology·W R Martin, M E Raichle
Nov 26, 1993·Neuroscience Letters·R DringenB Hamprecht
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmA Kleinschmidt
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·F HyderR G Shulman
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P G BittarP J Magistretti
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B Buxton, L R Frank
Apr 1, 1997·Cerebral Cortex·G L ShulmanS E Petersen
Jun 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X HuK Uğurbil
Jul 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S G Kim, K Uğurbil
Dec 16, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M M ToddB Wu
Sep 1, 1963·Neurology·N A LASSEND H INGVAR
Apr 1, 1936·Proceedings of the National Academy of Sciences of the United States of America·L Pauling, C D Coryell
Jan 1, 1890·The Journal of Physiology·C S Roy, C S Sherrington
Oct 1, 1997·Journal of Cognitive Neuroscience·G L ShulmanS E Petersen
Apr 1, 1989·Journal of Cognitive Neuroscience·S E PetersenM E Raichle

❮ Previous
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Citations

Feb 17, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K KashikuraI Kanno
Oct 23, 2001·Depression and Anxiety·J LevineW Drevets
May 25, 2005·Annals of Nuclear Medicine·Hiroshi ItoHiroshi Fukuda
May 4, 2010·Analytical and Bioanalytical Chemistry·Naoya TakahashiYuji Ikegaya
Sep 30, 2010·Experimental Brain Research·Hans C LouSarah H Lisanby
Sep 12, 2012·Experimental Brain Research·Bruce LuberSarah H Lisanby
Oct 31, 2009·Cognitive Processing·Klaus B BaerentsenAnders C Green
Nov 5, 2003·NeuroImage·John C Marshall, Gereon R Fink
Jan 5, 2000·Life Sciences·G S Berns
Sep 23, 2003·Brain Research. Brain Research Reviews·Alexander T Sack, David E J Linden
Sep 3, 2002·Journal of Neuroscience Methods·Anders H AndersenDon M Gash
Jun 25, 2002·Trends in Neurosciences·Gilles BonventoLuc Pellerin
Nov 26, 2002·Trends in Neurosciences·David Attwell, Costantino Iadecola
Aug 21, 2003·Progress in Neurobiology·R N A Henson
Jul 13, 1999·European Journal of Radiology·F Di SalleG Tedeschi
Nov 13, 2001·Pediatric Neurology·Y Frank, S G Pavlakis
Jan 13, 2001·Neural Networks : the Official Journal of the International Neural Network Society·M A ArbibE Oztop
Nov 25, 2000·Psychiatry Research·G K FrankJ C Price
May 16, 2000·Brain Research. Cognitive Brain Research·M LepageA R McIntosh
Apr 2, 2003·Brain Research. Cognitive Brain Research·Bart Rypma, Mark D'Esposito
Jun 17, 2003·Comptes rendus biologies·Robert G ShulmanDouglas L Rothman
Oct 5, 2001·Nature Reviews. Neuroscience·D A GusnardM E Raichle
Oct 13, 2006·Nature·Claire M PeppiattDavid Attwell
Dec 22, 2004·Nature Reviews. Neuroscience·Martin Lauritzen
Jan 13, 2000·Acta Physiologica Scandinavica·M FillenzA E Fray
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Francisco Fernández-KlettUte Lindauer
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·R G ShulmanF Hyder
Jun 1, 2007·Antioxidants & Redox Signaling·Obinna Ndubuizu, Joseph C LaManna
Oct 14, 2010·Journal of Neurotrauma·Zwany MettingJoukje van der Naalt
Mar 14, 2008·Brain : a Journal of Neurology·H Diana RosasSteven M Hersch

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