PMID: 8598536Jan 1, 1995Paper

Belactins A and B, new serine carboxypeptidase inhibitors produced by Actinomycete. I. Taxonomy, production, isolation and biological activities

Journal of Enzyme Inhibition
S MurakamiT Aoyagi

Abstract

Belactins A and B, new inhibitors of serine carboxypeptidase were discovered in the fermentation broth of Saccharopolyspora sp. MK19-42F6. They were purified by ethyl acetate extraction, silica gel chromatography, Sephadex LH20 chromatography, Capcellpak C18 SG120 reversed phase HPLC and centrifugal partition chromatography (CPC) following their inhibitory activity against carboxypeptidase Y (CP-Y). The inhibition constants (Ki) of belactins A and B against CP-Y are 0.14 and 0.27 microM respectively. Belactins A and B have highly specific inhibitory activities for CP-Y among various peptidases, have no antimicrobial activities at 100 micrograms/ml and have low toxicities.

References

Feb 1, 1978·Analytical Biochemistry·M HayakariH Izumi
Jun 1, 1978·The Journal of Antibiotics·H UmezawaT Takeuchi
Aug 1, 1978·The Journal of Antibiotics·S KondoT Aoyagi
Feb 1, 1991·International Journal of Peptide and Protein Research·K BreddamM Meldal
Jun 22, 1987·Biochimica Et Biophysica Acta·S HartelW Reutter
Feb 9, 1987·FEBS Letters·C CarlesB Ribadeau-Dumas
Feb 28, 1972·Biochimica Et Biophysica Acta·H OyaT Nagatsu
Aug 1, 1970·The Journal of Antibiotics·H UmezawaM Matsuzaki
May 1, 1966·Biochemistry·R M MetroioneJ S Fruton
Jan 1, 1981·The Journal of Clinical Investigation·T AoyagiH Umezawa
May 30, 1983·Biochimica Et Biophysica Acta·K FukasawaM Harada
Nov 1, 1982·The Journal of Antibiotics·K UotaniH Umezawa
Dec 1, 1980·The Journal of Antibiotics·H UmezawaS Takahashi

❮ Previous
Next ❯

Citations

Apr 17, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mehmet Nail NasirMagali Deleu
May 28, 2020·Organic & Biomolecular Chemistry·Dian Agung Pangaribowo, Manabu Abe
Sep 8, 2018·Natural Product Reports·Serina L RobinsonLawrence P Wackett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.