PMID: 8598537Jan 1, 1995Paper

Belactins A and B, new serine carboxypeptidase inhibitors produced by Actinomycete. II. Physico-chemical properties, structure determinations and enzymatic inhibitory activities compared with other beta-lactone containing inhibitors

Journal of Enzyme Inhibition
S MurakamiT Aoyagi

Abstract

Belactins A and B, new inhibitors of serine carboxypeptidase were discovered in the fermentation broth of Saccharopolyspora sp. MK19-42F6. The structures of belactins A and B were determined to be 4-[3-[(2-amino-5-chlorobenzoyl)amino]-1,1-dimethyl-2-oxobutyl]-3- methyl-2-oxetanone and 4-[3-[[2-(beta-glucopyranosylamino)-5-chlorobenzoyl]amino]-1,1- dimethyl-2-oxobutyl]-3-methyl-2-oxetanone respectively by various spectral analyses. Belactins A and B do not inhibit esterase or lipase at 100 micrograms/ml but have more specific inhibitory activities towards carboxypeptidase Y (CP-Y) compared with other beta-lactone-containing inhibitors, such as ebelactones A, B and esterastin.

References

Jun 1, 1978·The Journal of Antibiotics·H UmezawaT Takeuchi
Aug 1, 1978·The Journal of Antibiotics·S KondoT Aoyagi
Nov 1, 1982·The Journal of Antibiotics·K UotaniH Umezawa
Dec 1, 1980·The Journal of Antibiotics·H UmezawaS Takahashi

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Citations

May 28, 2020·Organic & Biomolecular Chemistry·Dian Agung Pangaribowo, Manabu Abe
Jan 6, 2019·Applied Microbiology and Biotechnology·Vera VilValery M Dembitsky

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