Benazepril, an angiotensin converting enzyme inhibitor: drug interaction with salbutamol and bronchial response to histamine in normal subjects

British Journal of Clinical Pharmacology
K G BauerG A Kaik

Abstract

To investigate the effect of the angiotensin converting enzyme inhibitor, benazepril, on pulmonary function. We investigated the influence of benazepril, on lung function and the interaction with inhaled salbutamol (0.1 to 6.6 mg) and histamine (0.03 to 30.69 g l-1) in normal subjects. Benazepril 20 mg, salbutamol 8 mg, propranolol 160 mg, and placebo were given orally once daily over 10 days. On day 8, there was no difference in the area under the salbutamol dose-response curves between benazepril, placebo and oral salbutamol (P > 0.05), propranolol shifted the curves to the right (P < 0.05). On day 10, histamine challenge resulted in following PD35sGaw values (geometric mean and 95% CI): with placebo 1.02 (0.95-1.09) g l-1, benazepril 1.04 (0.99-1.08), salbutamol 1.19 (1.13-1.25), propranolol 0.57 (0.50-0.65). Benazepril had no influence on baseline lung function, caused no interaction with inhaled salbutamol and the bronchial response to histamine was similar to placebo. However, our findings in normal subjects cannot be extrapolated automatically to asthmatics.

Citations

May 5, 2001·Expert Opinion on Pharmacotherapy·M A Faulkner, D E Hilleman
May 18, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Alessandro RubiniAndrea Parmagnani
Mar 24, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Alessandro RubiniEmanuele Luigi Carniel

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