Benazepril on tissue angiotensin-converting enzyme and cellular proliferation in restenosis after experimental angioplasty

Journal of Cardiovascular Pharmacology
J Li, C Wanchun

Abstract

We investigated the role of vascular angiotensin-converting enzyme (ACE) activity, cell proliferation, and the effect of different doses of benazepril on intimal hyperplasia after angioplasty in rabbits. Angioplasty was performed in all left iliac arteries in 28 rabbits. Benazepril was administrated to treatment groups in low (1 mg/kg/day) and high (10 mg/kg/day) doses. Two weeks after angioplasty, vascular ACE activity of the angioplasty subgroup was significantly higher than that of the nonangioplasty subgroup (from 0.44 to 1.19 nmol His-Leu/mg/min; p < 0.01). Strong correlation was demonstrated between vascular ACE activity and intimal area (r = 0.708; p < 0.01). Suppression of vascular ACE activity (59% decrease) and inhibition of intimal hyperplasia (43% decrease) was observed in the high-dose subgroup compared with the angioplasty subgroup without drug intervention (p < 0.01). But in the low-dose subgroup, the level of vascular ACE activity decreased moderately (24.4%; p < 0.05), and the intimal area did not alter significantly. Both the low and high dosage of benazepril resulted in a significant decrease in blood pressure (31 and 44 mm Hg, respectively). Striking correlation was displayed between proliferating-cell nucle...Continue Reading

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Citations

Jul 2, 2005·Expert Opinion on Emerging Drugs·J Linde, B H Strauss
Jan 10, 2009·The Veterinary Clinics of North America. Exotic Animal Practice·Romain Pariaut
Dec 10, 1999·Canadian Journal of Physiology and Pharmacology·W E Dale, E H Blaine
Feb 14, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Syeda H AfrozeShannon Glaser

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