Bench-to-bedside and bedside back to the bench; coordinating clinical and experimental traumatic brain injury studies.

Frontiers in Neurology
Denes V AgostonBo-Michael Bellander

Abstract

Traumatic brain injury (TBI) is one of the leading cause of death and long-term disability in virtually every country. Advances in neurointensive care have resulted in steadily decreasing morbidity, but the number of individuals with severe long-term disability have not changed significantly and the number of moderate disability has shown steady increase over the last 3 decades. Despite years of intensive preclinical research - and millions spent - there are virtually no drugs specifically developed to mitigate the consequences of TBI. Here we discuss some of the existing gaps between clinical and experimental TBI studies that may have contributed to the current status. We do this hoping that clinical, basic, and translational scientists will design and coordinate studies in order to achieve maximum benefits for TBI patients. In conclusion, we suggest to: (1) Develop consensus-based guidelines for experimental TBI research, similar to "best practices" in the clinic; (2) Generate a consensus-based template for clinical data collection and deposition as well as for experimental TBI data collection and deposition; (3) Use a systems biology approach and create a database for integrating existing data from basic and clinical research.

Citations

Mar 1, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael Ramsay
Nov 7, 2014·Frontiers in Neurology·Ibolja CernakStefan Plantman
May 15, 2018·Journal of Neurotrauma·Douglas S DeWittLiying Zhang
Oct 31, 2012·The Journal of Cell Biology·Lawrence Steinman
Aug 26, 2020·Journal of Neurotrauma·Douglas DeWitt, Donald S Prough
Jul 10, 2017·Concussion·Denes V Agoston, Dianne Langford

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Methods Mentioned

BETA
electron microscopy
gene knock-out

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.