Bench-to-bedside review: Neonatal sepsis-redox processes in pathogenesis.

Critical Care : the Official Journal of the Critical Care Forum
Ivan SpasojevićSnežana Spasić

Abstract

The present review is aimed at elucidating the neonatal 'sepsis redox cycle'--the cascade of inflammatory and redox events involved in the pathogenesis of sepsis in neonates. While adult and neonatal sepses share some common features, there are some substantial differences: higher mortality rates occur in adult sepsis and worse long-term effects are evident in neonatal sepsis survivors. Such epidemiological data may be explained by the lower ability of IL6 and IL8 to activate NF-κB-regulated transcription in neonatal sepsis in comparison to TNF-α, which is involved in the mechanisms of adult sepsis. The activation of NF-κB in neonatal sepsis is further promoted by hydrogen peroxide and results in mitochondrial dysfunction and energy failure as septic neonates experience decreased O2 consumption as well as lower heat production and body temperature in comparison to healthy peers. In neonates, specific organs that are still under development are vulnerable to sepsis-provoked stress, which may lead to brain, lung, and heart injury, as well as vision and hearing impairments. In the light of the processes integrated here, it is clear that therapeutic approaches should also target specific steps in the neonatal 'sepsis redox cycle' i...Continue Reading

Citations

Jan 26, 2013·PloS One·Stephan DreschersThorsten W Orlikowsky
Jan 23, 2016·Journal of Pediatric Gastroenterology and Nutrition·Vesna MarinkovićIvan Spasojević
May 16, 2014·Shock·Milica BajčetićIvan Spasojević
Nov 11, 2017·Inflammation·Amanda Della GiustinaFabricia Petronilho
Sep 4, 2018·Oxidative Medicine and Cellular Longevity·Chiara Poggi, Carlo Dani
Jan 1, 2014·International Scholarly Research Notices·A M Kosyreva
Oct 2, 2013·Annals of Clinical Biochemistry·Milica BajčetićIvan Spasojević
May 26, 2021·European Journal of Pharmacology·Zhe ChengJianghong Yan

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