Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury

American Journal of Physiology. Lung Cellular and Molecular Physiology
Lorraine B WareMichael A Matthay

Abstract

Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury (ALI). Findings from mouse, rat, baboon, and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in ALI and other inflammatory conditions in the lung including pneumonia, sepsis, and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/acute respiratory distress syndrome.

References

May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·E CamererS R Coughlin
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Riewald, W Ruf
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·K E Welty-WolfC A Piantadosi
Feb 19, 2002·The Journal of Biological Chemistry·Eric CamererShaun R Coughlin
Jan 4, 2003·The Journal of Clinical Investigation·Shaun R Coughlin, Eric Camerer
Apr 12, 2003·Critical Care Medicine·Wolfram Ruf, Matthias Riewald
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Martha Sue CarrawayClaude A Piantadosi
May 20, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lorraine B WareMichael A Matthay
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·W RufM Riewald
Jan 7, 2004·Critical Care Medicine·David S Bromet, Lloyd W Klein
Feb 12, 2004·British Journal of Haematology·Marcel Levi
Mar 8, 2005·American Journal of Respiratory and Critical Care Medicine·Tom van der PollEdward Abraham
Jun 18, 2005·Blood·Graciela AndoneguiPaul Kubes
Aug 3, 2005·Thorax·G ChoiC S Garrard
Aug 16, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karen E Welty-WolfClaude A Piantadosi
Oct 21, 2005·The Keio Journal of Medicine·Lorraine B WareLing Wang
Jan 26, 2006·Blood·Eric CamererShaun R Coughlin

❮ Previous
Next ❯

Citations

Nov 13, 2007·Intensive Care Medicine·John ArcaroliEdward Abraham
Aug 16, 2011·ACS Nano·Vladimir V ShuvaevVladimir R Muzykantov
Aug 25, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Julie A BastaracheLorraine B Ware
Oct 24, 2009·Journal of Applied Physiology·Anna A BirukovaKonstantin G Birukov
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Gordon D Rubenfeld, Edward Abraham
Aug 30, 2008·American Journal of Respiratory Cell and Molecular Biology·Fernando A BozzaGuy A Zimmerman
Jun 13, 2009·Critical Care : the Official Journal of the Critical Care Forum·Kathleen D LiuMichael A Matthay
Mar 16, 2007·Chest·Carolyn S Calfee, Michael A Matthay
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Alexander Zarbock, Klaus Ley
Aug 1, 2007·Biomarkers in Medicine·Carolyn S Calfee, Lorraine B Ware
Mar 17, 2010·Intensive Care Medicine·Thomas JaecklinBrian P Kavanagh
Dec 17, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Anna A BirukovaKonstantin G Birukov
Aug 4, 2009·Toxicology and Applied Pharmacology·Hye-Youn Cho, Steven R Kleeberger
Apr 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Christine L LauDavid J Pinsky
Feb 18, 2009·European Journal of Haematology·Laurens NieuwenhuizenDouwe H Biesma
May 27, 2009·British Journal of Pharmacology·Arne P NeyrinckMichael A Matthay
Feb 26, 2013·Journal of Thrombosis and Haemostasis : JTH·A D CornetA Beishuizen
Oct 13, 2009·Journal of Thrombosis and Haemostasis : JTH·T TakagiE C Gabazza
Jul 22, 2015·Archives of Toxicology·Hye-Youn Cho, Steven R Kleeberger
Mar 19, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sae-Kwang KuJong-Sup Bae
Apr 5, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vladimir V Shuvaev, Vladimir R Muzykantov
Aug 28, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Pin-Kuei FuChing-Liang Hsieh
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Pin-Kuei FuChing-Liang Hsieh
Jan 29, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Colin E Evans, You-Yang Zhao
May 19, 2009·Critical Care Medicine·Edward Abraham
Sep 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M J PerrioJ K Shute
Dec 3, 2009·Current Opinion in Critical Care·Angela J Frank, B Taylor Thompson
Oct 7, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sreerama ShettySteven Idell
Aug 22, 2013·Critical Care Medicine·Shun YuMichelle Ng Gong
Jan 10, 2008·The Journal of Pharmacology and Experimental Therapeutics·Mark A RichardsonBrian W Grinnell
Nov 20, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hailin ZhaoDaqing Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The New England Journal of Medicine
Lorraine B Ware, Michael A Matthay
American Journal of Respiratory and Critical Care Medicine
Michael A MatthayAndrea L Harabin
American Journal of Respiratory Cell and Molecular Biology
E Abraham
© 2022 Meta ULC. All rights reserved