Bendamustine, lenalidomide, and dexamethasone (BRD) is highly effective with durable responses in relapsed multiple myeloma

American Journal of Hematology
Shaji KumarRavi Vij

Abstract

Bendamustine is a multifunctional alkylating agent with single agent activity in myeloma. We designed the current phase 1/2 trial to determine the maximum tolerated doses (MTD) of bendamustine that can be safely combined with lenalidomide and dexamethasone and to assess the safety and efficacy of the combination. Patients with relapsed MM following at least 1 prior therapy, but no more than four lines of prior therapy and with measurable disease were enrolled. Bendamustine 75 mg/m(2) given on days 1 and 2, lenalidomide 25 mg given days 1-21 and dexamethasone 40 mg on days 1, 8, 15, and 22, was the recommended Phase 2 dose. Seventy-one patients were accrued: 21 on Phase 1 and 50 on Phase 2. The median age was 62.3 years; patients had a median of three prior lines of therapy (range 1-4), with over 70% of the patients having received prior lenalidomide, bortezomib, and/or peripheral blood stem cell transplant. Thirty-four of 70 (49%) patients had a confirmed partial response or better, including 20 patients (29%) with a very good partial response or better. An additional 4 patients had a minor response, translating to an overall 55% clinical benefit rate. Grade 3 or higher toxicity was seen in 96% of patients, with ≥grade 3 hemato...Continue Reading

References

May 23, 2001·Drugs·J A Balfour, K L Goa
Jul 21, 2006·Leukemia·B G M DurieUNKNOWN International Myeloma Working Group
Sep 6, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio PalumboUNKNOWN GIMEMA--Italian Multiple Myeloma Network
Aug 30, 2008·The New England Journal of Medicine·Jesús F San MiguelUNKNOWN VISTA Trial Investigators
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cyrille HulinPhilippe Moreau
Sep 29, 2011·British Journal of Haematology·Elisabeth Grey-DaviesFaith E Davies

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Citations

Dec 10, 2016·Annals of Hematology·Ariana BerensonJames R Berenson
Jul 18, 2018·Therapeutic Advances in Hematology·Sarah A HolsteinPhilip L McCarthy
Jun 11, 2020·Journal of Clinical Medicine·Roberto RiaAngelo Vacca
May 20, 2021·American Society of Clinical Oncology Educational Book·Jessica CaroFaith E Davies
Jun 3, 2021·Cancers·Fredrik Schjesvold, Albert Oriol

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