Bending properties, porosity, and ash fraction of black bear (Ursus americanus) cortical bone are not compromised with aging despite annual periods of disuse

Journal of Biomechanics
Kristin B Harvey, Seth W Donahue

Abstract

In many species, including humans, disuse causes an imbalance in bone remodeling that leads to increased bone porosity as a result of increased bone resorption and decreased bone formation. However, black bears (Ursus americanus) may not develop disuse osteopenia, to the extent that other animals do, during long periods of disuse (i.e. hibernation) because they maintain osteoblastic bone formation during hibernation, even though bone resorption is increased during hibernation. Black bears may also have a mechanism to rapidly and completely recover the bone lost (by increased resorption during hibernation) during their remobilization period. Our findings suggest that cortical bone bending strength (211-328 MPa), bending modulus (16.0-29.5 MPa), fracture energy (0.0118-0.0205 J mm(-2)), porosity (2.3-7.1%), and ash fraction (0.638-0.672) are not compromised with age in black bears, despite annual periods of disuse. In fact, the ultimate strength (p=0.01), modulus (p=0.04), and ash fraction (p=0.03) of cortical bone were shown to significantly increase with age (2-14 yrs). Female bears give birth and nurse during hibernation; however, we found no significant (p>0.16) differences between male and female bone properties. Other anima...Continue Reading

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Citations

Oct 10, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Meghan E McGee-LawrenceSeth W Donahue
May 3, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Simon Y TangTamara Alliston
Jun 25, 2005·Journal of Biomechanics·Seth W DonahueCharles T Robbins
Mar 27, 2015·International Journal of Endocrinology·Janina KueperJosh E Schroeder
Dec 10, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Luca H Fuller, Seth W Donahue
Jan 16, 2021·Bone·Seth W DonahueHal L Black
Apr 17, 2021·Scientific Reports·Anna V GoropashnayaVadim B Fedorov

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