Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats

Journal of Hypertension
Joep H M van EschA H Jan Danser

Abstract

The blood pressure-lowering effect of the renin inhibitor aliskiren equals that of angiotensin-converting enzyme (ACE) inhibitors and angiotensin (Ang) II type 1 (AT1) receptor blockers. Whether aliskiren offers end-organ protection remains to be investigated. Here, we compared the cardiac effects of aliskiren, the AT1 receptor blocker irbesartan and the ACE inhibitor captopril in spontaneously hypertensive rats (SHR) at equi-hypotensive doses. SHR were treated for 1-3 weeks with vehicle, aliskiren, captopril or irbesartan (100, 3 and 15 mg/kg per day, respectively) using an osmotic minipump, and compared to vehicle-treated Wistar-Kyoto (WKY) controls. All drugs lowered (but not normalized) mean arterial pressure in SHR equi-effectively, as monitored by radiotelemetry, without altering heart rate. All drugs also reduced the increased cardiomyocyte area in SHR, and tended to normalize the elevated brain natriuretic peptide plasma levels. In the Langendorff set-up, all drugs normalized the diminished endothelium-dependent vasodilator response to bradykinin in SHR. Moreover, aliskiren and irbesartan, but not captopril, decreased the enhanced coronary Ang II response in SHR. Aliskiren reduced plasma renin activity and the plasma an...Continue Reading

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Citations

Nov 26, 2010·Current Hypertension Reports·Ulrich M BecherNikos Werner
Jan 15, 2011·Current Hypertension Reports·Daniela Zablocki, Junichi Sadoshima
Apr 3, 2012·Current Hypertension Reports·Vadim Tchaikovski, Gregory Y H Lip
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Feb 18, 2016·Journal of Hypertension·Ebrahim BarkoudahNorman K Hollenberg
Jan 7, 2021·Clinical Science·Estrellita UijlA H Jan Danser

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