Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson's disease.

Journal of Neurology
Haidar S DafsariEUROPAR, the IPMDS Non Motor P.D. Study Group

Abstract

Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson's disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear. In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, -activities of daily living, and -complications (SCOPA-A, -B, -C), and levodopa-equivalent daily dose (LEDD) preoperatively, at 5 and 24 months follow-up. Longitudinal changes were analyzed with Friedman-tests or repeated-measures ANOVA, when parametric tests were applicable, and Bonferroni-correction for multiple comparisons. Post-hoc, visits were compared with Wilcoxon signed-rank/t-tests. The magnitude of clinical responses was investigated using effect size. Significant beneficial effects of STN-DBS were observed for PDSS, PDQ-8, SCOPA-A, -B, and -C. All outcomes improved significantly at 5 months with subsequent decrements in gains at 24 months follow-up which were significant for PDSS, PDQ-8, and SCOPA-B. Comparing baseline and 24 months follow-up, we observed significant...Continue Reading

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Citations

May 7, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Stefanie Theresa JostUNKNOWN EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson's Disease Study Group.
Oct 20, 2020·Journal of Parkinson's Disease·Stefanie T JostUNKNOWN EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group
Apr 8, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Hengameh ZahedSimon Little
Jun 10, 2021·NPJ Parkinson's Disease·Stefanie T JostUNKNOWN EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group
May 27, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Jarosław DulskiJarosław Sławek
Aug 28, 2021·Journal of Personalized Medicine·Valentina LetaK Ray Chaudhuri

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