Beneficial effect of angiotensin-blocking agents on graft fibrosis in hepatitis C recurrence after liver transplantation

Transplantation
Antoni RimolaJuan Rodes

Abstract

Hepatitis C recurrence after liver transplantation is often associated with accelerated graft fibrosis and progression to cirrhosis. Because drugs blocking the action of angiotensin-II can reduce fibrosis in different human and experimental models, we assessed the possible beneficial effect of these drugs on graft fibrosis in hepatitis C recurrence after liver transplantation. We retrospectively reviewed the charts of 128 liver-transplant recipients with hepatitis C recurrence. Twenty-seven patients (group I) received angiotensin converting enzyme inhibitors or angiotensin-II receptor antagonists as antihypertensive treatment, and 101 patients (group II) did not receive these drugs. No significant differences were found between groups I and II in demographic, clinical, and laboratory data. In contrast, cirrhosis in the graft was less frequently observed in group I than in group II during postransplant follow-up: 15% versus 35% (P=0.035), respectively, with a probability of cirrhosis of 9% versus 32% at 5 years after transplantation and 35% versus 70% at 10 years (P=0.0049). Furthermore, the fibrosis stage (scored from 0-4) in the liver biopsy obtained at the end of follow-up was significantly lower in group I than in group II (...Continue Reading

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References

Nov 1, 1991·Journal of Hepatology·P J Scheuer
Oct 1, 1995·The American Journal of Physiology·E A BurdmannW M Bennett
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
Mar 28, 1996·The New England Journal of Medicine·E J GaneR Williams
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CharltonJ Hoofnagle
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PrietoJ Berenguer
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z QiH Ueno
Apr 13, 1999·The American Journal of Physiology·S KanzlerM Blessing
Sep 9, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S C TextorJ E Augustine
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J CaoM Vore
Mar 10, 2001·Clinics in Liver Disease·S J MunozC Manzarbeitia
Sep 12, 2001·Hepatology Research : the Official Journal of the Japan Society of Hepatology·T OhishiH Ishii
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Oct 5, 2001·Seminars in Liver Disease·R Bataller, D A Brenner
Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D M BissellJ George
Oct 31, 2001·The British Journal of Surgery·J R Waller, M L Nicholson
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat Garcia-RetortilloJuan Rodes
Apr 20, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kelly W BurakMichael R Charlton
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuki TeruiShigeru Sakuta
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Giovanna CastoldiAndrea Stella
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ray Kim
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kemin ChenHelen Braley-Mullen
Nov 30, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tokihiko SawadaSatoshi Teraoka
Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Arantxa GonzálezJavier Díez
Jan 4, 2003·Gastroenterology·Marc G GhanyJay H Hoofnagle
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Erica VillaNicole G Lama
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Russell H WiesnerUNKNOWN International Liver Transplantation Society Expert Panel
Mar 16, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

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Citations

Dec 8, 2010·Digestive Diseases and Sciences·Barham K Abu DayyehRaymond T Chung
Mar 3, 2006·Current Gastroenterology Reports·Marzia Montalbano, Guy W Neff
May 7, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Hala M RaslanHassan E El-Batae
Aug 24, 2005·Antioxidants & Redox Signaling·Ramón BatallerDavid A Brenner
Jun 11, 2010·American Journal of Therapeutics·Ghulam AbbasKeith D Lindor
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Hitoshi YoshijiHiroshi Fukui
Jun 19, 2008·Journal of Gastroenterology and Hepatology·John S LubelPeter W Angus
Jul 25, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jordi ColmeneroPere Ginès
Oct 20, 2012·World Journal of Gastroenterology : WJG·Khanh vinh quốc Lương, Lan Thi Hoàng Nguyễn
Sep 12, 2012·World Journal of Gastrointestinal Pharmacology and Therapeutics·Marco CarboneLeonardo Baiocchi
Sep 18, 2013·Antioxidants & Redox Signaling·Yong-Han PaikDavid A Brenner
Aug 19, 2014·Clinics and Research in Hepatology and Gastroenterology·Armelle Poujol-RobertRaoul Poupon
Nov 30, 2012·AIDS Research and Treatment·Lindsey J ReeseDawn A Fishbein
Nov 11, 2006·Journal of Gastroenterology·Hitoshi Yoshiji, Hiroshi Fukui
Feb 4, 2011·Digestive Diseases and Sciences·Yavuz BeyazitIbrahim C Haznedaroglu
Feb 5, 2011·Expert Opinion on Therapeutic Targets·Shinji TakaiMizuo Miyazaki
Sep 1, 2009·Gastroentérologie Clinique Et Biologique·P CalèsM-C Rousselet
Jun 30, 2009·Gastroentérologie Clinique Et Biologique·A Mallat, S Lotersztajn
Nov 6, 2008·Clinics in Liver Disease·Montserrat Moreno, Ramon Bataller
Jul 4, 2007·Clinics in Liver Disease·Marina Berenguer
Mar 21, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G ParrilliG Marchesini
Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nassim KamarJacques Izopet
May 22, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Carlo FabrisMario Pirisi
Feb 18, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Kathleen E CoreyRaymond T Chung
Apr 26, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marina Berenguer
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Scott L FriedmanD Montgomery Bissell
Dec 29, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marina BerenguerJavier Zamora
May 28, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Valeria MasFederico Villamil
Feb 20, 2007·Transplant Immunology·Giuseppe TisoneMario Angelico
Oct 7, 2005·Clinics in Liver Disease·Marina Berenguer
Jan 21, 2015·Anesthesia and Analgesia·Ehab FaragD John Doyle
Oct 21, 2016·Expert Review of Gastroenterology & Hepatology·Elham AhmadianMohammad Ali Eghbal
Mar 25, 2016·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Qianqian ZhuZhengwen Liu
Apr 22, 2011·Experimental Biology and Medicine·M Kamruzzman MunshiShannon S Glaser
Jul 13, 2004·Journal of Hepatology·Montserrat Garcia-Retortillo, Xavier Forns
Feb 21, 2018·The Korean Journal of Internal Medicine·Kwang Yong ShimSoon Koo Baik

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