Beneficial effect of annexin A1 in a model of experimental allergic conjunctivitis

Experimental Eye Research
Alexandre Dantas GimenesSonia M Oliani

Abstract

Annexin A1 (ANXA1), a 37 kDa glucocorticoid-regulated protein, is a potent anti-inflammatory mediator effective in terminating acute inflammatory response, and its role in allergic settings has been poorly studied. The aim of this investigation was to evaluate the mechanism of action of ANXA1 in intraocular inflammation using a classical model of ovalbumin (OVA)-induced allergic conjunctivitis (AC). OVA-immunised Balb/c mice, wild-type (WT) and ANXA1-deficient (AnxA1(-/-)), were challenged with eye drops containing OVA on days 14-16 with a subset of WT animals pretreated intraperitoneally with the peptide Ac2-26 (N-terminal region of ANXA1) or dexamethasone (DEX). After 24 h of the last ocular challenge, WT mice treated with Ac2-26 and DEX had significantly reduced clinical signs of conjunctivitis (chemosis, conjunctival hyperaemia, lid oedema and tearing), plasma IgE levels, leukocyte (eosinophil and neutrophil) influx and mast cell degranulation in the conjunctiva compared to WT controls. These anti-inflammatory effects of DEX were associated with high endogenous levels of ANXA1 in the ocular tissues as detected by immunohistochemistry. Additionally, Ac2-26 administration was effective to reduce IL-2, IL-4, IL-10, IL-13, eota...Continue Reading

References

May 12, 1998·Clinical Immunology and Immunopathology·M T MagoneS M Whitcup
Feb 13, 2001·The American Journal of Pathology·S M OlianiM Perretti
Jan 4, 2003·The Journal of Clinical Investigation·Joonhong SohnSoo-Youl Kim
May 30, 2003·Nature Immunology·Dennis O GorNeil S Greenspan
Aug 19, 2004·Journal of Cellular Physiology·Girolamo PelaiaSerafino A Marsico
Mar 24, 2005·The Journal of Pharmacology and Experimental Therapeutics·Christianne Bandeira-MeloMarco A Martins
May 28, 2005·The American Journal of Pathology·Amilcar S DamazoMauro Perretti
Sep 1, 2005·Current Opinion in Allergy and Clinical Immunology·Michael E SternJerry Y Niederkorn
Jun 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A LeonardiV L Calder
May 17, 2007·International Archives of Allergy and Immunology·Atsuki FukushimaHisayuki Ueno
Sep 4, 2007·Experimental Eye Research·Virgilio G Bundoc, Andrea Keane-Myers
Oct 2, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S M OlianiM Perretti
Dec 20, 2008·The American Journal of Pathology·Thaís Santana GastardeloSonia Maria Oliani
Apr 10, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·So-Hyang ChungMi-Na Kweon
Jan 29, 2010·Investigative Ophthalmology & Visual Science·Xiaofen ZhengDe-Quan Li
May 22, 2010·The American Journal of Pathology·Jesmond DalliMauro Perretti
Sep 11, 2010·Current Opinion in Ophthalmology·James T Rosenbaum
Aug 9, 2011·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
Sep 20, 2011·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Paramdeep S BilkhuShehzad A Naroo
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F S P NgL H K Lim
Jan 10, 2012·Biochemical and Biophysical Research Communications·Sun Hwa LeeSoo Young Choi
May 9, 2012·Nature Medicine·Stephen J Galli, Mindy Tsai
Aug 21, 2013·Nature Reviews. Immunology·J Simon C Arthur, Steven C Ley
Dec 18, 2013·Journal of the American Academy of Dermatology·Joseph J ChenStephen C Pflugfelder

❮ Previous
Next ❯

Citations

Feb 18, 2016·Journal of Immunology Research·Michelle Amantéa SugimotoLirlândia Pires Sousa
Dec 21, 2016·European Journal of Immunology·Izabela GalvãoMauro M Teixeira
Jun 29, 2017·International Journal of Biological Macromolecules·Mengyi CongXia Zhao
Mar 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leandro G OliveiraAna Paula Fernandes
Mar 5, 2018·The British Journal of Ophthalmology·Frans Eberth Costa AndradeCristiane Damas Gil
Apr 5, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erika RicciCarlo Riccardi
Jun 7, 2019·Current Opinion in Allergy and Clinical Immunology·Nir ErdinestAbraham Solomon
Jun 19, 2016·Biological Chemistry·Thomas GrewalCarles Rentero
Dec 5, 2019·Frontiers in Pharmacology·Ajantha SinniahRod J Flower
Apr 16, 2019·FEBS Open Bio·Laila Toniol CardinFlávia Cristina Rodrigues-Lisoni
Jun 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Guoqiang HuaPierre Chambon
Nov 1, 2020·Medical Hypotheses·Andre Gustavo Bonavita
Dec 12, 2020·Microbial Pathogenesis·José Marcos SanchesCristiane Damas Gil
Jan 15, 2021·Cells·José Marcos SanchesCristiane D Gil
Apr 4, 2021·International Journal of Molecular Sciences·Thomas GrewalUrsula Rescher
May 12, 2020·Current Protein & Peptide Science·Huda Fatima RajaniMohammad Mahmoudi Gomari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved