PMID: 15374227Jul 1, 1995Paper

Beneficial effect of chronic nimodipine treatment on behavioral dysfunctions of aged rats exposed to perinatal ethanol treatment

Archives of Gerontology and Geriatrics
E MarkelCsaba Nyakas

Abstract

The long-term effects of prenatal and early postnatal ethanol exposure were assessed in adult (5-month), aged (24-month), and senescent (30-month) rats on non-aggressive intermale social behavior, and on black-white discrimination and spatial learning behaviors. Furthermore, the effects of chronic application of the Ca(2+) channel blocker nimodipine, which reportedly improves behavioral function in aging, were studied on the ethanol-induced behavioral deficits during aging. The results showed that the perinatal alcohol treatment suppressed social behavior by reducing the frequency and duration of social interactions at all ages. Black-white discrimination behavior and appetitively motivated learning in a hole-board were also markedly disturbed. Several measures of social and spatial learning behaviors of ethanol-exposed rats revealed progressive functional decline with aging. Chronic oral treatment with nimodipine improved the social activity and normalized the cognitive behavioral capabilities of aged and senescent rats exposed to ethanol. We concluded that: (1) the behavioral disabilities caused by perinatal ethanol toxicity are persistent in the rat lifespan and become more pronounced with aging; and (2) administration of ni...Continue Reading

References

Mar 29, 1979·Psychopharmacology·E P RileyN R Shapiro
Feb 1, 1979·Pharmacology, Biochemistry, and Behavior·E L Abel
Sep 1, 1989·Aging : Clinical and Experimental Research·Z S Khachaturian
Feb 10, 1989·Science·R A DeyoJ F Disterhoft
Jan 1, 1988·Physiology & Behavior·R L IsaacsonD M Vargas
Jul 1, 1987·Neurobiology of Aging·P W Landfield

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Citations

Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·T HarkanyC Nyakas
Oct 9, 2008·Neurochemical Research·C David Rollo
Aug 6, 2011·Alcoholism, Clinical and Experimental Research·Michael W ChurchBrittany R Adams
May 1, 1996·Progress in Neurobiology·C NyakasP G Luiten

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