Beneficial effect of cyclosporine A on traumatic hemorrhagic shock

The Journal of Surgical Research
Yan LeiTao Li

Abstract

Vascular hyporeactivity plays an important role in severe trauma and shock. We investigated the beneficial effect of cyclosporine A (CsA) on traumatic shock and its relationship to vascular reactivity improvement and mitochondrial permeability transition pore (MPTP). Sodium pentobarbital-anesthetized rats were used to induce traumatic hemorrhagic shock by left femur fracture and hemorrhage, the beneficial effects of CsA (1, 5, and 10 mg/kg, intravenously) on animal survival, cardiovascular function, tissue blood perfusion, and mitochondrial function of vital organs were observed. In addition, hypoxia-treated vascular smooth muscle cells from normal rats were used to investigate the relationship of this beneficial effect of CsA to Rho-associated serine/threonine kinase (ROCK) and protein kinase C. CsA prolonged the survival time and increased the 24-h survival rate of traumatic hemorrhagic shock (31%, 56%, and 56% in 1, 5, and 10 mg/kg CsA group versus 25% in lactated Ringer solution group). Five milligrams per kilogram of CsA had the best effect, which stabilized and improved the hemodynamics, increased the tissue blood flow, and improved the liver and kidney function including its mitochondrial function in shock rats. CsA had ...Continue Reading

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Citations

Mar 19, 2016·Molecular BioSystems·Nancy E WitowskiGreg J Beilman
Jun 12, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Luisa Berenise Gamez-GonzalezMarco Yamazaki-Nakashimada
Jul 13, 2016·Shock·Melissa A Kottke, Thomas J Walters
Jan 23, 2021·The Journal of Surgical Research·Yang LiuLongbin Liang
Feb 5, 2021·International Immunopharmacology·Qiuyi GuiLuyong Zhang

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