Beneficial effect of fluoxetine on anti-tumor progression on hepatocellular carcinoma and non-small cell lung cancer bearing animal model.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Li-Cho HsuI-Tsang Chiang

Abstract

Fluoxetine, an antidepressant, has been indicated to elicit anti-cancer response in hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC) in vitro. However, anticancer effect and mechanism of fluoxetine in HCC and NSCLC in vivo still needs to be elucidated. In this study, we showed anticancer efficacy and inhibitory mechanism of fluoxetine on the tumor progression of HCC and NSCLC in vivo. Tumor growth was significantly inhibited with fluoxetine treatment in HCC and NSCLC in vivo. Fluoxetine obviously decreased expression of cell proliferative, anti-apoptotic, invasion-associated proteins including Cyclin-D1, survivin, vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP-9) and urokinase-type plasminogen activator (uPA). Importantly, fluoxetine diminished the phosphorylation of NF-κB p65 which recognized as one of the critical transcription factors in tumor progression. Inhibition of AKT or extracellular signal-regulated kinases (ERK) phosphorylation was linked to NF-κB inactivation in NSCLC or HCC in vitro. Furthermore, expression of AKT or ERK phosphorylation was effectively attenuated by fluoxetine treatment in NSCLC or HCC in vivo. In addition, fluoxetine also triggered extrinsic/intrins...Continue Reading

Citations

Jan 12, 2021·Drug and Alcohol Dependence·Vincent Chin-Hung ChenMichael E Dewey
Aug 28, 2021·Experimental and Therapeutic Medicine·Weilong LiBaoyuan Li
Nov 4, 2021·Drug Discovery Today·Yihui SongBin Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Medicina : revista della Enciclopedia medica italiana
P Tiraboschi, A Spagnoli
The New England Journal of Medicine
S L Blomgren, G D Tollefson
The New England Journal of Medicine
A CastiellaJ I Arenas
Deutsche medizinische Wochenschrift
C H Gleiter, H P Volz
The Australian Nurses' Journal
C Purdon
© 2021 Meta ULC. All rights reserved