Beneficial effect of hyperbaric oxygen on island flaps subjected to secondary venous ischemia

Microsurgery
Thomas J GampperMichael F Angel

Abstract

The potential for hyperbaric oxygen therapy (HBO) to decrease the untoward effects of a secondary ischemic event was studied in the rat superficial epigastric flap model. The secondary venous ischemic flap was created by cross-clamping the vascular pedicles for 2 h. Twenty-four hours later, the flap was reelevated and the venous pedicle was occluded for 5 h. Thirty-two rats were divided into three groups. In experimental group 1, animals received HBO treatment immediately prior to the initial flap elevation and ischemia at 2 atmosphere pressures for 90 min. In experimental group 2, the rats underwent a similar course except for a second 90-min HBO course immediately prior to the secondary venous occlusion. The rats without HBO therapy were used as controls. The results showed that all control flaps were nonviable at 1 week by clinical inspection and fluorescein injection. Complete flap survival occurred in 20% of group 1 flaps and 30.8% of group 2 flaps. Partial flap survival occurred in the rest of the flaps in these two groups, with mean survival areas of 48% and 55%, respectively. In conclusion, HBO treatments significantly increase the survival of flaps subjected to a secondary ischemia, even if administered before the prim...Continue Reading

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Oct 11, 2002·Microsurgery·Dorthe M AndresenVibeke E Hjortdal
Sep 25, 2003·Plastic and Reconstructive Surgery·Maziar ShafighiHildegunde Piza-Katzer
Jan 30, 2004·Microsurgery·Jerone T LandströmGeorge P Macris
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Feb 11, 2021·Plastic and Reconstructive Surgery. Global Open·Florian BoissiereBenoit Chaput
Aug 26, 2021·Journal of Plastic Surgery and Hand Surgery·İlknur BayırKemal Deniz

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