PMID: 2485483Jan 1, 1989Paper

Beneficial effect of intrarenal verapamil in human acute renal failure

Renal Failure
D LumlertgulG Sangchun

Abstract

Cellular Ca2+ influx during the reperfusion period after an ischemic insult has been proposed to be a crucial pathogenetic factor in the development of experimental acute renal failure (ARF). The present study, therefore, examined the potential beneficial effect of intrarenal verapamil, a calcium entry blocking agent, on ARF in patients. Twelve patients were enrolled in the study. Six ARF patients (experimental group)--ARF caused by malaria (4 patients) and leptospirosis (2 patients)--had a catheter placed in their renal artery; verapamil was infused at 100 micrograms/min for 3 h and intravenous furosemide, 0.8 mg/kg/h x 24 h was also administered. Another six ARF patients (control group)--ARF caused by malaria (5 patients) and leptospirosis (1 patient)--were treated with intravenous furosemide alone. Baseline renal function was comparable in both groups; GFR (3.16 +/- 3.24 vs 0.7 +/- 1.5 mL/min, NS), serum creatinine (Scr), (9.1 +/- 2.1 vs 11.3 +/- 2.2 mg/dL, NS), and urine volume (V) (41.79 +/- 4.77 vs 34.54 +/- 13.52 mL/h, NS), were comparable in the experimental and control groups. Twenty-four hours posttreatment, the increment of GFR (9.66 +/- 4.25 vs 1.32 +/- 0.50 mL/min, P less than .02) and V (181.8 +/- 61.7 vs 79 +/- 1...Continue Reading

References

Jan 1, 1976·Nephron·D KleinknechtJ Fermanian
Sep 1, 1987·Kidney International·R W SchrierT J Burke
Mar 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·D GoldfarbH E Eliahou

❮ Previous
Next ❯

Citations

Dec 9, 1995·Lancet·H R Brady, G G Singer
Nov 30, 2000·Anesthesiology Clinics of North America·P K Schoenwald
Jun 1, 1994·Kidney International·S N RahmanJ D Conger
Oct 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D Conger
Jan 1, 1994·Renal Failure·G TataranniG Zavagli
Aug 28, 2002·The Annals of Pharmacotherapy·Maria C Pruchnicki, Joseph F Dasta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.