Beneficial effect of intravenous magnesium during endoscopic submucosal dissection for gastric neoplasm

Surgical Endoscopy
Ji Eun KimSo Yeon Kim

Abstract

Endoscopic submucosal dissection (ESD) has been revealed as an effective treatment of early gastric neoplasm and should be performed under sedation with adequate pain control. Magnesium sulfate has analgesic, sedative, and sympatholytic properties. This study examined the effects of intravenous magnesium 50 mg/kg administered before ESD for gastric neoplasm on analgesic and sedative consumptions during ESD and pain after ESD. In this randomized, double-blind, and prospective study, patients undergoing ESD randomly received either intravenous magnesium sulfate 50 mg/kg (magnesium group n = 30) or the same volume of normal saline (control group n = 30) over 10 min before the start of sedation. Fentanyl consumption during ESD was the primary end point. Hemodynamics was recorded during the procedure, and abdominal pain was evaluated at 30 min, 6 h, and 24 h after ESD. During ESD, fentanyl consumption was 24 % less in the magnesium group than in the control group (96 ± 27 vs. 126 ± 41 μg, mean ± SD; p = 0.002), although there was no significant difference in propofol consumption (p = 0.317). In addition, magnesium attenuated the elevation of mean blood pressure at the time of epinephrine submucosal injection (p = 0.038) and 5 min af...Continue Reading

References

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Citations

Feb 11, 2016·Journal of Gastroenterology and Hepatology·Zhanwei ZhaoQingchuan Zhao
Oct 18, 2016·Current Opinion in Gastroenterology·Samuel HanWahid Y Wassef
May 21, 2019·Frontiers in Pharmacology·Ismar Lima CavalcantiNubia Verçosa
Sep 16, 2020·European Journal of Pharmacology·Chuan-Feng TangLing-Dong Kong
May 1, 2021·Nutrients·Véronique MorelGisèle Pickering

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