Beneficial effect of nerve growth factor-7S on peripheral nerve regeneration through inside-out vein grafts: an experimental study

Microsurgery
Andreas I GravvanisJohn D Ioannovich

Abstract

This study investigated the effect of local administration of nerve growth factor-7S (NGF-7S) on the axonal regrowth of mixed peripheral nerves through inside-out vein grafts. Sixty male Wistar rats were randomized into two groups (n = 30). A defect 12 mm long in the right sciatic nerve was created and repaired with an inside-out vein graft from the right jugular vein. NGF-7S (group A) or phosphate-buffered saline (group B; control) was locally administered daily during the first 3 weeks. Walking-track analysis and electrophysiological and histological-morphometric studies were carried out 4, 6, 8, 10, and 12 weeks postoperatively (subgroups a, b, c, d, and e, respectively, n = 6 each). Data analysis showed that 1) the recovery of motor function, as measured by walk pattern analysis and evoked muscle action potential, and 2) the orientation, number, myelin thickness, and diameter of myelinated fibers were better in the NGF-7S than in the control group. These findings present strong evidence of the beneficial effect of NGF-7S on peripheral nerve regeneration through inside-out vein grafts.

References

Jan 1, 1989·Plastic and Reconstructive Surgery·J R BainD A Hunter
Jul 1, 1988·Journal of Reconstructive Microsurgery·N SuematsuT Hirayama
Oct 15, 1986·Brain Research·A J Windebank, J F Poduslo
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A D LanderL F Reichardt
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·E S AntonW D Matthew
Jan 1, 1993·Microsurgery·K K WangB R Seckel
Aug 1, 1996·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·I H WhitworthG Terenghi
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Oct 21, 1998·Microsurgery·K K WangC L Cetrulo
Oct 8, 1999·Plastic and Reconstructive Surgery·L L PuJ G Thomson
Oct 16, 1999·The Anatomical Record·F FerrariC R Padovani
Dec 30, 1999·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·M WibergG Terenghi
Jun 13, 2000·Alzheimer Disease and Associated Disorders·M E Jönhagen
Dec 21, 2000·British Journal of Plastic Surgery·M O KelleherM A Glasby
Mar 5, 2003·Microsurgery·Alécio Santos BarcelosCarlos R Padovani

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Citations

Sep 8, 2005·Microsurgery·Byung-Ho ChoiByung-Yong Kim
Jun 15, 2007·Biomedical Microdevices·Shan-hui HsuChien-Hsiang Su
Apr 2, 2008·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Jie TangMeng-chun Qi
Dec 3, 2010·Plastic and Reconstructive Surgery·Thomas ScholzGregory R D Evans
Mar 13, 2014·Journal of Brachial Plexus and Peripheral Nerve Injury·Stefano GeunaBruno Battiston
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Aikeremujiang MuheremuJiang Peng
Dec 20, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Rahim MohammadiSeyedeh-Sepideh Sajjadi
Jan 13, 2010·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Baoguo JiangBailin Jiang
May 9, 2012·The Journal of Surgical Research·Rahim MohammadiKeyvan Amini
May 4, 2013·Microsurgery·Martina LichtenfelsJefferson Braga-Silva
Nov 18, 2005·Injury·Peter V Giannoudis, Ippokratis Pountos
Oct 19, 2011·Journal of Food Protection·Ho S Phang, Christine M Bruhn
May 9, 2008·Critical Reviews in Food Science and Nutrition·Corliss A O'BryanDennis G Olson
Jul 1, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ecem Sevim LongurAyça Karagöz Köroğlu
Feb 6, 2017·Advanced Healthcare Materials·Martina GiannacciniVittoria Raffa
Jun 6, 2021·BMC Complementary Medicine and Therapies·Young Jun KimSeung-Yeon Cho

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