Beneficial effect of pentoxifylline on thyroid associated ophthalmopathy (TAO)*: a pilot study

The Journal of Clinical Endocrinology and Metabolism
C BalázsN R Farid

Abstract

We have previously found that pentoxifylline (Ptx) inhibited cytokine induced HLA-DR expression and glycosaminoglycan (GAG) synthesis by retroorbital fibroblasts. We have now tested the clinical efficacy of Ptx in treating TAO. Ten patients with moderately severe ophthalmopathy were selected for study. All patients were euthyroid before and during the 12 weeks of the Ptx therapy. Serum GAG, TNF-alpha, anti-TSH-receptor, anti-eye muscle, anti-thyroglobulin and anti-thyroid peroxidase antibodies were determined sequentially. At the end of 12 weeks eight of the ten patients showed improvement in soft tissue but not in proptosis or extraocular muscle involvement. At baseline the levels of GAG (5.2+/-0.92 mg/dl v.s. 0.7+/-0.14 mg/dl, p<0.001) and TNF-alpha (33.6+/-6.6 pg/ml v.s. 5.4+/-1.3 pg/ml, p<0.001) were increased in patients compared to controls. They gradually decreased in the eight patients who responded to Ptx: after 4, 8 and 12 weeks of therapy serum GAG was 3.4+/-0.42 mg/dl, 2.5+/-0.77 mg/dl (p<0.01) and 1.1+/-0.2 mg/dl (p<0.001), respectively and serum TNF-alpha was 20.9+/-4.8 pg/ml, 14.9+/-2.2 pg/ml (p<0.05) and 9.7+/-1.8 pg/ml (p<0.01), respectively. Serum GAG and TNF alpha did not fall in the two patients who did not ...Continue Reading

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Citations

Jul 17, 2012·Archivos de la Sociedad Española de Oftalmología·I Genol SaavedraA Nogueira Goriba
Aug 12, 2014·Orvosi hetilap·Annamária ErdeiV Endre Nagy
Oct 24, 2012·Orvosi hetilap·Boglárka Türke, Csaba Balázs
Nov 29, 2011·Survey of Ophthalmology·Khayyam DurraniC Stephen Foster
Jun 24, 2008·Current Eye Research·Ahmet HondurBerati Hasanreisoglu
Mar 9, 2002·Journal of Endocrinological Investigation·C Balázs, N R Farid
May 20, 2011·The New England Journal of Medicine·Claudio MarcocciUNKNOWN European Group on Graves' Orbitopathy
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Jan 1, 2021·Frontiers in Endocrinology·Giulia LanzollaMichele Marinò

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