PMID: 11311961Apr 20, 2001Paper

Beneficial effect of supplementation with copper sulfate on STZ-diabetic mice (IDDM)

Diabetes Research and Clinical Practice
S SitasawadP Parab

Abstract

Trace element status is known to be altered in the diabetic state. Current evidence suggests that reactive oxygen intermediates (ROI's) do participate in the destruction of pancreatic beta cells in STZ-induced Type 1 diabetes. The copper and zinc status of diabetic patients and their descendants was also found to have changed. The aim of this study was to evaluate the potential usefulness of copper sulfate in the treatment of STZ-induced type I diabetes. We used C57BL6 female mice, in whom copper sulfate treatment was started at 6 weeks of age followed by an IP injection of 40 mg/kg body weight of STZ for five consecutive days. Its effects were evaluated at 10 weeks of age. The treatment with copper sulfate significantly decreased blood glucose levels, levels of lipid peroxidation and mRNA expression of the enzyme iNOS and the cytokines IFN-gamma and IL-4. Histological analysis of the pancreas revealed that, three out of five animals in the copper sulfate treated groups showed absence of mononuclear cell infiltration and no change in the shape and size of islets as compared to pancreas of the STZ-induced diabetic group of animals. In conclusion, our observations indicate that copper sulfate treatment can exert beneficial effect...Continue Reading

References

Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P W Gray, D V Goeddel
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A CorbettM L McDaniel
Aug 1, 1996·Biological Trace Element Research·A S Abdul-GhaniR Amin
Oct 1, 1996·British Journal of Pharmacology·K Kamata, T Kobayashi
Nov 1, 1996·Diabetologia·K YamadaK Nonaka
Aug 26, 1998·Developmental Immunology·M L LukićA Shahin
Dec 29, 1998·Immunology Today·H Kolb, V Kolb-Bachofen
May 20, 1999·Transplantation Proceedings·Y M ShewadeR R Bhonde

❮ Previous
Next ❯

Citations

Feb 7, 2013·Frontiers of Medicine·Xiao MiaoLu Cai
Nov 14, 2013·Biological Trace Element Research·Giovanni ForteRoberto Madeddu
Mar 4, 2005·Treatments in Endocrinology·Dominique Bonnefont-Rousselot
Jul 20, 2012·International Journal of Biological Sciences·Omotayo O ErejuwaMohd S Ab Wahab
Sep 22, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·S CivelekG Burçak
Dec 3, 2010·The Journal of Nutrition, Health & Aging·A PizentR Mujagic
Jun 20, 2008·Medical Hypotheses·Charles Edward Weber
Dec 22, 2011·Metallomics : Integrated Biometal Science·Clare Duncan, Anthony R White
Apr 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·Lu Cai
May 12, 2004·Journal of Inorganic Biochemistry·Katherine H ThompsonChris Orvig
Dec 1, 2006·International Journal of Food Sciences and Nutrition·Noori S Al-WailiAmjed Ali
Jan 11, 2007·Physiological Genomics·Chana YagilYoram Yagil
Mar 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Sarah Weksler-ZangenItamar Raz
Jan 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Sarah Weksler-ZangenAnn Saada
Sep 3, 2019·Current Medicinal Chemistry·Geir BjørklundJan Aaseth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.