Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2.

International Journal of Food Sciences and Nutrition
Jelena StanisicGoran Koricanac

Abstract

Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.

References

Jan 1, 1995·Journal of Molecular and Cellular Cardiology·Z Xiong, N Sperelakis
Feb 14, 1998·Hypertension·S I PomposielloO A Carretero
Sep 2, 1999·Current Biology : CB·B J MichellR B Pearson
Jan 21, 2000·Hypertension·W F Jackson
Nov 12, 2003·The EMBO Journal·Sven MoosmangNorbert Klugbauer
Oct 1, 2004·American Journal of Physiology. Cell Physiology·Shen ZhangHui Dong
Jan 19, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshio TanakaLigia Toro
Jan 21, 2006·The Journal of Nutrition·Paul DavisWallace Yokoyama
Mar 28, 2006·The Journal of Nutritional Biochemistry·Bernhard HennigMichal Toborek
Mar 10, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Thomas BrennaUNKNOWN International Society for the Study of Fatty Acids and Lipids, ISSFAL
Jun 10, 2011·Journal of Molecular and Cellular Cardiology·Ryuji TsuburayaHiroaki Shimokawa
May 2, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yunjun XiaoXuefen Su
Dec 9, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mauricio A LilloXavier F Figueroa
Feb 2, 2018·Nature Reviews. Cardiology·Charlotte FarahJean-Luc Balligand
Feb 2, 2018·The Journal of Clinical Investigation·Sarah A HannouMark A Herman
Feb 9, 2018·Nutrition Research·Nopporn ThangthaengBarbara Shukitt-Hale
Sep 2, 2018·Indian Heart Journal·Ravindra BhardwajNavin Nanda
Nov 1, 2018·Physiological Reviews·Jesús TejeroMark T Gladwin
Jan 11, 2019·Nutrients·Samantha MorgilloAlison M Coates
Apr 2, 2019·Current Pharmaceutical Design·Alexa CroitoruEcaterina Andronescu
Apr 25, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun ChengYan Yang

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