Beneficial effects and safety of corticosteroids combined with traditional chinese medicine for pemphigus: a systematic review

Evidence-based Complementary and Alternative Medicine : ECAM
Tingting ZhouXiaosong Liu

Abstract

Objective. To evaluate the beneficial effects and safety of corticosteroids combined with traditional Chinese medicine (TCM) for pemphigus. Methods. Seven electronic databases were searched to identify any potential randomized controlled trials (RCTs) or clinical controlled trials (CCTs) that compared corticosteroids with and without TCM for the treatment of pemphigus, published in any language. Remission of the mucocutaneous lesions, therapeutic duration, dosage of corticosteroids, and specific antibody titers were employed as the main outcome measures. The methodological quality of the included studies was assessed using the Cochrane Handbook for Systematic Review of Interventions and Rev Man 5.1.0 software. Results. Four RCTs with a total of 199 patients were included in the present review. Management with corticosteroids combined with TCM seemed to benefit pemphigus patients in terms of healing of lesions, prevention of complications and relapse, and reduced interferon-gamma (IFN-γ) level. The trials were not of high methodological quality. No study mentioned allocation concealment and blinding. Only one trial reported adverse events, and it indicated that the safety of corticosteroids combined with TCM was uncertain. Concl...Continue Reading

References

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Jan 16, 2014·Autoimmunity Reviews·Ruben KershenovichDaniel Mimouni

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Citations

May 23, 2019·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Oznur FidanOzgen Aras
Apr 22, 2020·Journal of Drug Targeting·Dongjian ZhangJian Zhang

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