Beneficial effects of 1-year captopril therapy in children with chronic aortic regurgitation who have no symptoms

American Heart Journal
D Alehan, S Ozkutlu

Abstract

This prospective study was performed to assess the effects of 1 year of angiotensin-converting enzyme inhibition with captopril in 20 children (mean age 14.3+/-2.3 years) with asymptomatic chronic aortic regurgitation. At 12 months patients receiving captopril had a significant reduction in left ventricular end-diastolic and end-systolic dimensions (57+/-9.3 vs 51+/-9.5 mm, p < 0.001; 35.4+/-6.1 vs 32+/-6.8 mm, p < 0.001), end-diastolic and end-systolic volume indexes (111+/-36 vs 94+/-29 ml/m2, p < 0.001; 35+/-13 vs 30+/-12 ml/m2, p < 0.001, respectively), and mass index (138+/-37 vs 109+/-32 gm/m2, p < 0.0001) determined by two-dimensional echocardiography. Meridian (p < 0.01) and circumferential (p < 0.0001) wall stresses also decreased significantly with therapy. Significant reduction (27.8%, p < 0.0001) was achieved in regurgitant fraction with captopril. These data show that the long-term therapy with angiotensin-converting enzyme inhibitors is able to reverse left ventricular dilation and hypertrophy and suggest that such therapy has the potential to favorably influence the natural history of the disease in children.

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Citations

Aug 25, 2004·Current Treatment Options in Cardiovascular Medicine·Ian Balfour
Sep 30, 2005·The New England Journal of Medicine·Artur EvangelistaJordi Soler-Soler
Jan 19, 2016·Heart, Lung & Circulation·Thomas G WilsonYves d'Udekem
Nov 14, 2006·Cardiology Clinics·Konstantinos DimopoulosMichael A Gatzoulis
Aug 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kevin O Maher, James S Tweddell
Jun 12, 2013·Expert Review of Cardiovascular Therapy·Rafael Alonso-Gonzalez, Konstantinos Dimopoulos
Feb 24, 2006·Paediatric Drugs·Kazuo Momma
Jan 18, 2012·Current Opinion in Cardiology·Kathleen E Simpson, Charles E Canter
Feb 24, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Aliocha Scheuble, Alec Vahanian

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