Beneficial effects of 6-shogaol on hyperglycemia, islet morphology and apoptosis in some tissues of streptozotocin-induced diabetic mice

Diabetology & Metabolic Syndrome
Jun-Koo YiSung-Hyun Kim

Abstract

Diabetes is characterized by hyperglycemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The aim of the present study was to investigate the effects of ginger on various tissues (i.e., pancreas, kidney, and liver) and insulin resistance in streptozotocin-induced diabetic mice. The pleasant aroma of ginger comes from the constituents present in its volatile oil, while its non-volatile pungent phytochemicals consist of gingerols, shogaols, and paradols. This research was conducted to determine the effects of 6-shogaol administration on blood glucose and insulin production in type 1 diabetic mice. Mice were intraperitoneally injected with shogaol at 5 or 10 mg/kg body weight. Untreated mice were injected with an equivalent volume of buffer, three times a week for 2 weeks. The animals were randomly divided into four experimental groups: control group mice (n = 3) were given an intraperitoneal (IP) injection of streptozotocin (STZ) vehicle (1 mL citrate buffer/100 g body weight) at day 1 and received an IP injection of 6-shogaol vehicle [1 mL buffer (0.5% DMSO, 10% Tween 20, and 89.5% PBS)/100 g body weight] every other day for 4 consecutive da...Continue Reading

References

Mar 1, 1991·Diabetes·S V McLennanJ R Turtle
Jan 1, 1982·Critical Reviews in Food Science and Nutrition·V S Govindarajan
Jan 1, 1982·Critical Reviews in Food Science and Nutrition·V S Govindarajan
Feb 9, 1993·Biochemical Pharmacology·A K SaxenaN Z Baquer
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Young-Joon Surh
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Tatsuya KurokiGeorge L King
Dec 13, 2005·Journal of Clinical Gastroenterology·Stephen A Harrison
Dec 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yogeshwer Shukla, Madhulika Singh
Oct 24, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badreldin H AliAbderrahim Nemmar
Nov 15, 2008·Journal of Molecular and Cellular Cardiology·Xiaoqing HeQiang Ma
Apr 16, 2009·Forum of Nutrition·Joydeb Kumar KunduYoung-Joon Surh
Oct 14, 2009·Hemoglobin·Wei WeiLu Cai
Oct 17, 2009·Journal of Ethnopharmacology·Swarnalatha DugasaniJayaveera Narsimha Korlakunta
Oct 30, 2010·Circulation Research·Ferdinando Giacco, Michael Brownlee
Dec 28, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kondeti Ramudu ShanmugamKesireddy Sathyavelu Reddy
Apr 13, 2011·Molecular Immunology·Paola I IngaramoCristina E Carnovale
Mar 13, 2012·International Journal of Molecular Sciences·Chung-Yi ChenHui-Min Wang
Jul 6, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min-Ji BakWoo-Sik Jeong
Apr 25, 2013·Food & Function·Raghavendra HaniadkaManjeshwar Shrinath Baliga
Nov 16, 2013·Diabetologia·Lorena MarselliPiero Marchetti
Jun 10, 2014·Lancet·Yuankai Shi, Frank B Hu

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Image
Pro plus

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis