Beneficial effects of a lifestyle intervention program on C-reactive protein: impact of cardiorespiratory fitness in obese adolescents with sleep disturbances

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Johanna RocheFabienne Mougin

Abstract

The objectives of this study were to assess the relationship between inflammation and obstructive sleep apnea (OSA) and determine whether the lifestyle program's effects on inflammatory markers are associated with changes in anthropometric parameters, cardiorespiratory fitness, sleep duration, and OSA severity in severely obese adolescents. Participants were aged 14.6 (SD 1.2) yr, with a body mass index (BMI) of 40.2 (SD 6.5) kg/m2. Sleep, anthropometric parameters, glucose metabolism, inflammatory profile, and cardiorespiratory fitness [V̇o2peak relative to body weight (V̇o2peakBW) and fat-free mass (V̇o2peakFFM)] were assessed at admission and at the end of a 9-mo lifestyle intervention program (LIP). Associations between C-reactive protein (CRP) concentrations and BMI, sex, oxygen desaturation index (ODI), sleep fragmentation, total sleep time (TST), and V̇o2peak were assessed via ANCOVA. Twenty-three subjects completed the study. OSA subjects ( n = 13) exhibited higher CRP concentrations and a trend for higher BMI than non-OSA subjects ( P = 0.09) at admission. After intervention, OSA was normalized in six subjects, and CRP significantly decreased in the OSA group and in the whole population. In both groups, leptin levels s...Continue Reading

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Citations

Jan 9, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Johanna RocheDavid Thivel
Feb 29, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Almudena Carneiro-BarreraGualberto Buela-Casal
Feb 6, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Johanna RocheFabienne Mougin

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Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT02588469

Software Mentioned

SleepRT
XLSTAT
SleepSense
Graphpad

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