Beneficial effects of a new fluid regime on kidney function of donor and recipient during laparoscopic v open donor nephrectomy

Journal of Endourology
Ingrid R A M Mertens zur BorgDiederik Gommers

Abstract

Laparoscopic donor nephrectomy (LDN) has been associated with delayed graft function compared with open donor nephrectomy (ODN). We have recently shown that the adverse effect of pneumoperitoneum (PP) on hemodynamics could be prevented by a new fluid regime. The aim of this study was to test the effect of this fluid regime on the kidney function of the donor and recipient after LDN and ODN. We prospectively collected data of 51 donors undergoing ODN and 59 donors undergoing LDN as well as data from the corresponding recipients. All donors and recipients were treated with a standardized anesthesia and fluid regime. This fluid regime consisted of preoperative overnight hydration together with a bolus of colloid administered before induction of anesthesia and before introduction of PP. Follow-up was 2 years. Baseline characteristics of the two groups were comparable. Hemodynamics and urine output until nephrectomy were comparable between both groups. Donor kidney function did not differ after ODN and LDN. Estimated glomerular filtration rate, graft survival, and recipient survival did not differ between open and laparoscopically procured transplants. No adverse effects of the novel fluid regime (eg, pulmonary edema or additional o...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Aug 10, 1995·The New England Journal of Medicine·P I TerasakiS Takemoto
Oct 1, 1994·Journal of Endourology·D T ChangI S Sawczuk
Apr 1, 1994·Journal of Endourology·A W ChiuR K Babayan
Nov 14, 1997·Annals of Surgery·J L FlowersS T Bartlett
Dec 23, 1999·The Journal of Trauma·J M DotyD A Sica
May 3, 2000·Kidney International·L R Kavoussi
Jun 27, 2000·Transplantation·L E RatnerL R Kavoussi
Aug 2, 2000·Archives of Surgery·T M SasakiJ A Light
Jul 18, 2001·The Journal of Urology·M D StifelmanS Shichman
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Joseph F BuellE Steve Woodle
Sep 27, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christoph TroppmannRichard V Perez
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Todd V BrennanSandy Feng
Mar 9, 2005·Transplantation·Hemender S VatsChristie P Thomas
Mar 30, 2005·BJU International·Nasser SimforooshSeyed M M Hosseini Moghaddam
Mar 30, 2006·Transplantation·Niels F M KokJan N M IJzermans
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M H AndersenE Fosse

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Citations

Nov 30, 2013·Anesthesiology Clinics·Michael D Spiro, Helge Eilers
Sep 2, 2008·The Urologic Clinics of North America·David A Duchene, Howard N Winfield
Nov 19, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Eline K van den AkkerFrank J M F Dor
Aug 16, 2015·Surgical Endoscopy·Denise M D Özdemir-van BrunschotMichiel C Warlé

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