Beneficial effects of aminoguanidine on the cardiovascular system of diabetic rats

Diabetes/metabolism Research and Reviews
Krisztián StadlerJudit Jakus

Abstract

The study focused on investigating the effect of aminoguanidine on cardiovascular damages in diabetes and the possible mechanisms of its action. Aminoguanidine (AMNG) was used to treat streptozotocin-induced diabetic rats, and the effects were compared to those obtained under insulin treatment. Blood metabolic parameters, *NO and ONOO- as well as protein carbonyl levels and cardiac hypertrophy were determined. Diabetic animals showed increased *NO levels and markedly increased ONOO- generation in the aorta, along with a significant hypertrophy and protein carbonylation in the cardiac tissue. Both AMNG and insulin treatment suppressed the levels of overproduced *NO or ONOO- in the vasculature, but only AMNG was able to prevent hypertrophic alterations and reduce protein carbonylation in the cardiac tissue. Oxidative protein modification, together with cardiac hypertrophy and high generation of *NO and ONOO-, are important early events in the development of cardiovascular complications in diabetes. Aminoguanidine could prevent hypertrophy through inhibition of production of nonenzymatic glycation products rather than via inhibition of *NO production.

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Citations

Oct 19, 2007·Zeitschrift für Gerontologie und Geriatrie·N NassA Simm
Apr 12, 2011·PloS One·Yasuhiko MatsumotoKazuhisa Sekimizu
Apr 8, 2014·Journal of Molecular Modeling·Christian Solís-CaleroFrancisco Muñoz
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