Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters

Japanese Journal of Pharmacology
Kenichi OkumuraMizuo Miyazaki

Abstract

This study was performed to determine whether angiotensin (Ang) II-forming enzymes, angiotensin converting enzyme (ACE) and chymase might contribute to the development of adriamycin-induced cardiomyopathy in hamsters. Hamsters were administered adriamycin (2.0 mg/kg per day, i.p.) three times weekly for 2 weeks. In the ACE inhibitor-treated group, the hamsters received lisinopril (20 mg/kg per day, p.o.) for 2 weeks after the last injection of adriamycin. The 4-week mortality rates of the vehicle- and ACE inhibitor-treated hamsters were 44% and 12%, respectively. In comparison to the age-matched hamsters used as the control hamsters, a significant decrease in cardiac function and a significant increase in the ratio of the heart weight to the body weight were observed in the vehicle hamsters. Cardiac ACE activity, but not the chymase activity, in the vehicle hamsters was significantly increased in comparison to that in the control hamsters. In the ACE inhibitor-treated group, the increased ACE activity was reduced significantly, and the cardiac hypertrophy and dysfunction were improved significantly. In adriamycin-induced cardiomyopathic hamsters, cardiac ACE activity was increased and ACE inhibition significantly improved cardi...Continue Reading

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Citations

Nov 26, 2008·Current Treatment Options in Cardiovascular Medicine·Daniela CardinaleCarlo Maria Cipolla
May 27, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohamed A IbrahimSalama R Abdel-Rahim
Dec 6, 2005·International Journal of Cardiology·Mayako SogaYoshifusa Aizawa
Jun 26, 2012·International Journal of Cardiology·Mehmet G KayaYat Yin Lam
Apr 25, 2016·Current Cardiology Reports·Daniela CardinaleCarlo Maria Cipolla
Dec 3, 2014·Clinical Biochemistry·Eric S ChristensonBen H Park
Apr 24, 2014·Journal of the American Heart Association·Virginia Shalkey HahnBonnie Ky
Aug 20, 2009·Cardiology in Review·Kuldeep Maradia, Maya Guglin
Jan 7, 2010·Journal of Cardiovascular Pharmacology·Olfat Shaker, Doaa A Sourour
Sep 12, 2020·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Ahmed Ayuna, Nik Abidin
Jul 10, 2020·Journal of Cardiovascular Translational Research·Kajaluxy Ananthan, Alexander R Lyon
Nov 21, 2008·Postgraduate Medicine·Ashley SimmonsDavid Meyers
Sep 18, 2020·Journal of Cardiovascular Medicine·György FogarassyTamás Forster

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