Beneficial effects of biota, a traditional Chinese herbal medicine on learning impairment induced by basal forebrain-lesion in mice

Biological & Pharmaceutical Bulletin
N NishiyamaH Saito

Abstract

The effects of biota (Biota orientalis ENDL.) on learning impairment produced by bilateral lesion of basal forebrain in mice were studied using step-through and step-down type passive avoidance tasks. Basal forebrain-lesion was generated by applying radiofrequency current. Behavioral experiment, started 15d after the survey, revealed prominent delay in the memory acquisition process in the lesioned mice. The operation also induced memory retention deficit in both learning tests. Chronic oral administration of ethanol extract of biota seeds at doses of 250 and 500 mg/kg/d, from the day of surgery until the end of the behavioral test, dose-dependently improved memory acquisition impairment in the step-down test and memory retention disturbance in both behavioral tasks. The preparation also had a tendency to alleviate memory acquisition impairment in the step-through test. Although precise action mechanisms of biota extract remains speculative, such as what component works on which target, the present results clearly suggest that the preparation affects the learning and memory processes in the central nervous system and improves the impairment of memory acquisition and retention disturbances produced by basal forebrain-lesion.

Citations

Feb 19, 2002·Journal of Ethnopharmacology·S M P GalvãoE A Carlini
Aug 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nelson G M GomesCarlos A F Ribeiro
Sep 15, 2007·Phytochemistry·Ya-Zhou WangYang Ye
Mar 12, 2002·Japanese Journal of Pharmacology·K AraiN Nishiyama
Aug 8, 2007·Archives of Pharmacal Research·Tran Manh HungKiHwan Bae
Mar 13, 2009·Archives of Pharmacal Research·Guang-Hua XuIck-Dong Yoo
Jan 1, 2005·Pharmaceutical Biology·Seyed Ahmad EmamiAbbas Jafarian
Feb 28, 2018·Frontiers in Aging Neuroscience·Devesh TewariAtanas G Atanasov
Sep 2, 2008·Biological & Pharmaceutical Bulletin·Jun-ichi MorishigeKiyoshi Satouchi
Oct 3, 2002·Molecular and Cellular Neurosciences·Tatyana StrekalovaMelitta Schachner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.