Beneficial Effects of Coenzyme Q10 Supplementation on Lipid Profile and Intereukin-6 and Intercellular Adhesion Molecule-1 Reduction, Preliminary Results of a Double-blind Trial in Acute Myocardial Infarction

International Journal of Preventive Medicine
Mona MohseniAbbas Rahimi Forushani

Abstract

The present investigation was aimed to improve the inflammatory factors and lipoproteins concentration in patients with myocardial infarction (MI) by supplementation with coenzyme Q10 (CoQ10). In a double-blind, placebo-controlled study, we measured serum concentrations of one soluble cell adhesion molecules (intercellular adhesion molecule-1 [ICAM-1]), serum concentration of intereukin-6 (IL-6) and lipid profiles (high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], total cholesterol and triglyceride [TG]) in CoQ10 supplementation group (n = 26) compared with placebo group (n = 26) in hyperlipidemic patients with MI. Fifty-two patients were randomized to receive 200 mg/day of CoQ10 or placebo for 12 weeks. There were no significant differences for serum LDL-C, total cholesterol, and TG between two mentioned groups after the intervention. A significant enhancement in serum HDL-C level was observed between groups after the intervention (55.46 ± 6.87 and 44.07 ± 6.99 mg/dl in CoQ10 and placebo groups, respectively P < 0.001). Concentrations of ICAM-1 (415.03 ± 96.89 and 453.38 ± 0.7 ng/dl CoQ10 and placebo groups, respectively, P = 0.001) and IL-6 (11 ± 9.57 and 12.55 ± 8.76 pg/ml CoQ10 and p...Continue Reading

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Citations

Jan 17, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Heba SeragAmira Adly
Jun 17, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shiva TaghizadehBahram Pourghassem Gargari
Feb 17, 2018·Critical Reviews in Food Science and Nutrition·Francisco M Gutierrez-MariscalJose Lopez-Miranda
Oct 30, 2020·International Journal of Molecular Sciences·Francisco Miguel Gutierrez-MariscalJose López-Miranda
Jul 3, 2021·Antioxidants·Francisco M Gutierrez-MariscalJosé López-Miranda

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS
Statistical Package for Social Sciences

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