Beneficial effects of continuous subcutaneous insulin infusion and flexible multiple daily insulin regimen using insulin glargine in type 1 diabetes

Pediatrics
R AlemzadehDavid T Wyatt

Abstract

The aim of this study was to evaluate the metabolic effects of continuous subcutaneous insulin infusion (CSII) with flexible multiple daily insulin (FMDI; premeal lispro + bedtime glargine) therapy as determined by glycosylated hemoglobin (HbA1c), body mass index (BMI), and hypoglycemic episodes in a group of patients who made the transition from multiple daily insulin (premeal lispro + bid ultralente) to either CSII or FMDI therapy. Data from 40 (27 female and 13 male) patients (10.1-17.8 years of age) who were on CSII and 40 age- and gender-matched (27 female and 13 male) patients (10.3-17.3 years of age) who were on FMDI were collected during regularly scheduled visits at a similar frequency over a 1-year period. The total daily insulin dose did not change in CSII (0.97 +/- 0.24 vs 0.91 +/- 0.22 U/kg) and FMDI (0.98 +/- 0.21 vs 0.97 +/- 0.21 U/kg) patients, whereas the bolus:basal insulin ratio was significantly increased in both CSII (1.01 +/- 0.43 vs 1.32 +/- 0.52) and FMDI (1.07 +/- 0.0.41 vs 1.29 +/- 0.47) patients. The total cohort of CSII patients showed a decrease in HbA1c from 8.4 +/- 1.0% to 7.8 +/- 0.8%, whereas the FMDI cohort did not show a significant change in HbA1c (8.5 +/- 1.1% to 8.2 +/- 0.9%). However, 40% ...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Aug 1, 1997·Diabetologia·S BottI Mühlhauser
May 20, 1999·Diabetes Care·A G RassamD S Schade
Feb 10, 2000·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research GroupDavid M Nathan
Jul 20, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G B Bolli
Oct 27, 2001·Diabetes Care·C AllenUNKNOWN Wisconsin Diabetes Registry Project
Apr 30, 2002·Hormone Research·E Standl
Mar 29, 2003·Diabetes Care·H Peter Chase
Jul 2, 2003·Diabetes Care·Carol HomkoGuenther Boden

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Citations

Aug 30, 2005·Diabetes Research and Clinical Practice·E ColinoR Barrio
Feb 17, 2009·Diabetes Technology & Therapeutics·Ghufran S BabarRamin Alemzadeh
Apr 27, 2013·Diabetes Technology & Therapeutics·Neale D CohenJonathan Shaw
Oct 4, 2008·The Diabetes Educator·Carla JohnsLauretta Quinn
Apr 3, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rachel L HayesGeoffrey R Ambler
Jan 29, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·L Tapia Ceballos
Jul 8, 2009·Drug Discovery Today·Jennifer SherrWilliam V Tamborlane
Oct 31, 2008·Diabetes & Metabolism·N JeandidierB Guerci
Dec 25, 2004·Diabetes/metabolism Research and Reviews·Riccardo SchiaffiniAntonino Crinó
Jan 29, 2008·Pediatric Diabetes·Minna PäivärintaRiitta Veijola
Jun 16, 2006·Pediatric Diabetes·Thomas DanneOlga Kordonouri
Jun 16, 2006·Pediatric Diabetes·Ragnar Hanas, Johnny Ludvigsson
Aug 30, 2008·The Mount Sinai Journal of Medicine, New York·Jennifer Sherr, William V Tamborlane
Jan 28, 2009·Diabetes/metabolism Research and Reviews·Daniela BruttomessoAldo Baritussio
Jul 27, 2006·Basic & Clinical Pharmacology & Toxicology·Henriette ThistedJørgen Rungby
Jan 24, 2008·Pediatric Diabetes·Jesper JohannesenJørn Nerup
Jun 14, 2015·Diabetes Research and Clinical Practice·I Overgaard IngeholmUNKNOWN DSBD
Feb 3, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kevin KaisermanJessie L Fahrbach
Jul 9, 2016·Pediatric Diabetes·Kevin KaisermanMyriam Rosilio
Nov 23, 2005·Pediatric Clinics of North America·Marianna RachmielDenis Daneman
Jul 25, 2018·Pediatric Diabetes·Jennifer L SherrDavid M Maahs
Dec 14, 2019·American Journal of Therapeutics·Revital NimriMoshe Phillip
Dec 22, 2019·Diabetes Care·UNKNOWN American Diabetes Association
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Sep 7, 2016·Journal of Diabetes Science and Technology·Jenise C WongUNKNOWN T1D Exchange Clinic Network
Dec 11, 2020·Diabetes Care·UNKNOWN American Diabetes Association
Oct 4, 2006·Pediatrics·Erica A EugsterUNKNOWN Lawson-Wilkins Drug and Therapeutics Committee

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