Beneficial effects of curcumin on antitumor activity and adverse reactions of doxorubicin

International Journal of Pharmaceutics
Yasuyuki SadzukaTakashi Sonobe

Abstract

Many medicines used in cancer chemotherapy decrease the quality of life (QOL). It is believed that an increase in food intake during cancer chemotherapy may produce an improvement in QOL. Curcumin is widely used as a coloring and flavoring agent in food. The effects of curcumin in relation to the chemotherapeutic drug doxorubicin (DOX) were examined. While DOX alone did not decrease tumor weight, the combination of DOX and curcumin significantly reduced tumor weight to 56.5% (p<0.05) of that of the control group. The combined curcumin enhanced apoptosis by DOX and decreased cell viability. The curcumin-DOX combination also suppressed activation of caspase-3, -8, and -9 compared to DOX alone. It is presumed that combining curcumin increased DOX-induced antitumor activity by suppressing the main caspase pathway and activating the main caspase independent pathway. The combination of curcumin and DOX suppressed the reduction of glutathione peroxidase activity and increased lipid peroxide levels in the heart. Therefore, it is expected that curcumin may reduce the adverse reactions associated with DOX. Our results suggest that curcumin can be used as a modulator to enhance the therapeutic index of cancer patients and improve their QOL.

References

Mar 21, 1991·The New England Journal of Medicine·J H Doroshow
Dec 1, 1966·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T A Connors
Apr 5, 2000·The Journal of Biological Chemistry·R J AntoD Karunagaran
May 30, 2001·Advanced Drug Delivery Reviews·K Jung, R Reszka
May 7, 2002·Nature Reviews. Cancer·Laurence H Hurley
Dec 3, 2002·Annals of Internal Medicine·Wendy A WeigerDavid M Eisenberg
May 15, 2004·Cancer Letters·G Radhakrishna PillaiEwa Carrier
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ricky A SharmaWilliam P Steward
Feb 1, 2005·Life Sciences·Hideki MizutaniShosuke Kawanishi
Apr 28, 2005·Free Radical Biology & Medicine·Satyendra MishraKrishna Misra
Aug 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A SharmaW P Steward
Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal
Sep 2, 2009·Biological & Pharmaceutical Bulletin·Yasuyuki SadzukaTakashi Sonobe
Sep 8, 2009·International Journal of Pharmaceutics·Yasuyuki SadzukaTakashi Sonobe

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Citations

Mar 4, 2014·Biological & Pharmaceutical Bulletin·Michiko Miyashita, Yasuyuki Sadzuka
Jun 4, 2013·Current Opinion in Biotechnology·Anat Eldar-BoockRonit Satchi-Fainaro
Dec 29, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Shizhu ChenXing-Jie Liang
Mar 24, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Han CaoZhengzhong Shao
Sep 22, 2015·International Journal of Pharmaceutics·Haoyu LiYanjun Zhao
Sep 24, 2015·Journal of Food Science and Technology·Lokesh PathakYadvendra Agrawal
Nov 7, 2013·Pharmaceutical Development and Technology·Lindsay A WegielLynne S Taylor
Nov 7, 2016·Pharmaceutical Research·Tapan K Dash, V Badireenath Konkimalla
Sep 21, 2017·Molecular and Cellular Biochemistry·Aditi Jain, Vibha Rani
May 23, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ashley G MullerGillian A Hutcheon
Jun 20, 2014·Experimental and Therapeutic Medicine·Yaosheng TuYuxing Chen
Dec 6, 2017·International Journal of Oncology·Shuli ChenRhonda J Rosengren
Nov 26, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jinfeng ShiGeorge Pak-Heng Leung
Nov 20, 2016·International Journal of Pharmaceutics·Rebecca KlippsteinKhuloud T Al-Jamal

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