Beneficial effects of dantrolene on lipopolysaccharide-induced haemodynamic alterations in rats and mortality in mice

European Journal of Pharmacology
C C Wu, M H Yen

Abstract

We investigated the effect of dantrolene, an inhibitor of Ca2+ release from the sarcoplasmic reticulum, on the induction of nitric oxide (NO) synthase II by bacterial endotoxin (lipopolysaccharide) in the anaesthetised rat and on survival in a murine model of severe endotoxaemia. Injection of lipopolysaccharide (i) induced biphasic changes of rectal temperature and blood glucose: an initial increased phase (< 180 min after injection of lipopolysaccharide) followed by a decreased phase (at 240-360 min), (ii) caused a fall in mean arterial blood pressure from 115 +/- 3 mmHg (time 0) to 83 +/- 6 mmHg at 360 min, (iii) resulted in a substantial hyporeactivity to noradrenaline (1 microg/kg i.v.), (iv) raised plasma nitrate (an indicator of NO formation) in a time-dependent manner, (v) elicited a significant increase in NO synthase II activity in the lung and (vi) caused a 80% lethality (in mice). Pretreatment of animals with dantrolene not only attenuated the delayed circulatory failure, but also prevented the overproduction of NO and the induction of NO synthase II caused by lipopolysaccharide in the rat, and improved survival in a murine model of severe endotoxaemia. Thus, dantrolene has beneficial haemodynamic effects in animals ...Continue Reading

References

Jan 1, 1992·Cardiovascular Research·C E WrightS Moncada
Nov 20, 1990·European Journal of Pharmacology·G A GrayJ C Stoclet
Sep 14, 1990·Biochemical and Biophysical Research Communications·I FlemingJ C Stoclet
Nov 15, 1990·Biochemical and Biophysical Research Communications·R G KilbournR F Lodato
Jan 1, 1986·Journal of Cardiovascular Pharmacology·C van BreemenR Loutzenhiser
Feb 15, 1988·Biochemical and Biophysical Research Communications·I WakabayashiK Nagai
Sep 2, 1987·European Journal of Pharmacology·I WakabayashiK Nagai
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K O Ellis, S H Bryant
Jan 1, 1984·Microbiology and Immunology·S SakaguchiO Sakaguchi
Jun 1, 1982·Critical Care Medicine·B ChernowC R Lake
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Nov 1, 1994·Journal of Cardiovascular Pharmacology·S J ChenM H Yen
Mar 1, 1995·Trends in Pharmacological Sciences·C van BreemenI Laher
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A MitchellJ R Vane
Mar 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P A van Zwieten, M Pfaffendorf
Feb 15, 1963·Science·D F Bohr

❮ Previous
Next ❯

Citations

Sep 26, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C Y LiY A Ding
May 14, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C Y LiY A Ding
Jul 17, 1999·European Journal of Pharmacology·C C WuM H Yen
Mar 21, 1998·Critical Care Medicine·R S Hotchkiss, I E Karl
Mar 4, 2003·Journal of Cellular and Molecular Medicine·B O PopescuL M Popescu
May 18, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Selma DüzenliAkçahan Gepdiremen
Jun 19, 2013·The Journal of Surgical Research·Mei-Hui LiaoChin-Chen Wu
Apr 23, 2003·Anesthesia and Analgesia·Sungsam ChoKoji Sumikawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.