PMID: 8949826Sep 1, 1996Paper

Beneficial effects of dexmedetomidine on ischaemic myocardium of anaesthetized dogs

British Journal of Anaesthesia
P M H J RoekaertsS de Lange

Abstract

We have studied the effect of dexmedetomidine during coronary artery stenosis (CAS) in dogs. Three periods of 15 min of CAS were induced at 40-min intervals in two groups of dogs (dexmedetomidine compared with placebo). Dexmedetomidine was administered before the second and third periods of CAS in doses of 1 and 3 micrograms kg-1, respectively. Dexmedetomidine decreased plasma concentrations of noradrenaline by mean 71 (SEM 9)%, heart rate by 8 (4)%, cardiac output by 30 (6)% and increased mean arterial pressure by 23 (10)%. Dexmedetomidine reduced blood flow in non-ischaemic myocardium and in the ischaemic epicardial layer by 16 (8)%, but blood flow was preserved in the ischaemic mid-myocardial and subendocardial layers. Consequently, dexmedetomidine increased the ischaemic-non-ischaemic blood flow ratio. Dexmedetomidine did not change myocardial oxygen consumption but decreased myocardial oxygen demand from 4.91 (0.33) to 3.76 (0.25) mumol min-1 g-1, thereby reducing the oxygen deficiency of the ischaemic myocardium from 1.47 (0.37) to 0.29 (0.32) mumol min-1 g-1.

Citations

Sep 13, 2011·Pediatric Cardiology·Joseph D TobiasAndrew R Yates
Oct 12, 2012·Pediatric Cardiology·Francis LamPunkaj Gupta
Jan 22, 2009·Cardiology in the Young·Sharon BejianBrigham C Willis
Feb 3, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joseph D Tobias
Nov 18, 2009·Regional Anesthesia and Pain Medicine·Volkan HanciIşil Ozkoçak Turan
Sep 9, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Avihu Z Gazit
Feb 6, 2008·Journal of Cardiothoracic and Vascular Anesthesia·R Blaine Easley, Joseph D Tobias
Jul 12, 2016·Best Practice & Research. Clinical Anaesthesiology·Hans-Joachim Priebe
Apr 1, 2008·Current Therapeutic Research, Clinical and Experimental·Hasan KocogluNebahat Gulcu
May 10, 2005·Veterinary Anaesthesia and Analgesia·Joanna C Murrell, Ludo J Hellebrekers
Feb 25, 2003·Anesthesia and Analgesia·Henriëtte M WilligersMarcel E Durieux
Feb 22, 2005·European Journal of Anaesthesiology·H M M WilligersP M H J Roekaerts
Aug 31, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Huishu WangLiangcheng Zhang
Jul 5, 2017·Experimental and Therapeutic Medicine·Ke PengFu-Hai Ji
Nov 21, 2017·Turkish Journal of Medical Sciences·Mediha TürktanAtakan Atalay
Jun 20, 2020·Journal of Intensive Care Medicine·Tara L RuderMukhtar Al-Saadi
Jul 22, 2004·Anaesthesia and Intensive Care·A KulkarniG Skowronski
Dec 22, 2005·Proceedings·R GertlerE N Silvius
Oct 8, 2020·Acta Cirúrgica Brasileira·Mustafa Sırrı KotanoğluMeliha Korkmaz
Jan 9, 2008·Veterinary Anaesthesia and Analgesia·Guan-Yu LinLudo J Hellebrekers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of Cardiothoracic and Vascular Anesthesia
J JalonenM Valtonen
Journal of Cardiothoracic and Vascular Anesthesia
P M H J RoekaertsS de Lange
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Punkaj GuptaStephen J Roth
© 2021 Meta ULC. All rights reserved