Abstract
We aimed to evaluate the clinical performance of early administration of recombinant human B-type natriuretic peptide (rhBNP) to ST-elevation myocardial infarction (STEMI) patients receiving percutaneous coronary intervention (PCI) treatment. In total, 185 patients diagnosed with STEMI were enrolled and randomised into either the placebo-treated (n = 88) or rhBNP-treated (n = 97) group. Patients were given either saline or rhBNP ten minutes before PCI and monitored with various cardiac parameters, including accelerated idioventricular rhythm, frequent ventricular premature beat (FVPB), ventricular tachycardia, systolic blood pressure, thrombolysis in myocardial infarction (TIMI) 3 gradation, corrected TIMI frame count (cTFC) and myocardial blush grade (MBG) 3 classification. Our results revealed no difference in accelerated idioventricular rhythm between the two groups. However, FVPB and ventricular tachycardia were significantly decreased in rhBNP-treated patients compared to placebo-treated patients (p < 0.05). Moreover, the occurrence ratio of reperfusion-associated low blood pressure in rhBNP-treated patients was lower than in placebo-treated patients (p = 0.03), while no difference was observed in infarction-related arteri...Continue Reading
References
Aug 1, 1996·Cardiovascular Research·Y TakataC Ibukiyama
Jun 25, 1998·Circulation·A W van 't HofF Zijlstra
Jul 27, 2000·The New England Journal of Medicine·W S ColucciT H LeJemtel
Mar 28, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Publication Committee for the VMAC Investigators (Vasodilatation in the Management of Acute CHF)
Dec 19, 2002·Drugs·Gillian M Keating, Karen L Goa
Jan 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Savio P D'SouzaGary F Baxter
May 14, 2003·Circulation·Andrew D MichaelsKanu Chatterjee
Jan 13, 2004·The American Journal of Cardiology·Uri ElkayamAhsan Usman
May 29, 2004·Current Opinion in Critical Care·Christophe AdrieChristian Spaulding
Oct 21, 2004·British Medical Bulletin·Holger K Eltzschig, Charles D Collard
Nov 17, 2004·Circulation·Rika KawakamiKazuwa Nakao
Jan 5, 2005·Clinical Cardiology·Francesco BellandiRoberto Piero Dabizzi
May 16, 2006·Heart·Michael Weber, Christian Hamm
Oct 16, 2007·Heart·L A Piérard
May 21, 2008·European Heart Journal·Shu KasamaMasahiko Kurabayashi
Nov 26, 2008·Basic Research in Cardiology·Wen ZhaoEvangelia G Kranias
Sep 11, 2009·Clinical Cardiology·James B YoungRoger M Mills
Jul 8, 2011·The New England Journal of Medicine·C M O'ConnorR M Califf
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Apr 29, 2014·American Heart Journal·Kevin R Bainey, Paul W Armstrong
Jul 1, 2014·World Journal of Cardiology·Rodrigo Estévez-LoureiroFelipe Fernández-Vázquez