Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

Pharmaceutical Biology
Mohammad Taghi MansouriAlireza Sarkaki

Abstract

Context In a previous study, it has been shown that ellagic acid (EA), a polyphenolic compound found in pomegranate and different berries, prevents cognitive and hippocampal long-term potentiation (LTP) impairments induced by traumatic brain injury in rats through antioxidant and anti-inflammatory mechanisms. Objective The present study was conducted to assess the potential of EA as a memory enhancer. Materials and methods The elevated plus maze (EPM) and passive avoidance (PA) paradigm were used to evaluate learning and memory parameters. Three doses (10, 30 and 100 mg/kg, i.p.) of EA were administered to animals. Memory impairment was induced by scopolamine treatment (0.4 mg/kg, i.p.) and/or diazepam (1 mg/kg, i.p.). Acquisition trials were carried out 30 min after scopolamine treatment and retention trials were performed for 5 min 24 h after the acquisition trials. Results EA at doses 30 and 100 mg/kg significantly reversed the amnesia induced by scopolamine (0.4 mg/kg, i.p.) in the EPM and PA tests in mice. Also, EA at doses 30 and 100 mg/kg significantly antagonized the amnesia induced by diazepam (1 mg/kg, i.p.) in EPM test in rats. Moreover, chronic administration of EA at dose 30 mg/kg ameliorated the memory deficit ind...Continue Reading

References

Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R G Lister
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·M H Thiébot
Nov 1, 1995·Brain Research. Brain Research Reviews·A Blokland
Jan 1, 1997·Life Sciences·S D Iversen
Apr 4, 2002·Journal of Agricultural and Food Chemistry·Subramani SellappanGerard Krewer
Oct 25, 2003·Oncogene·Danyelle M Townsend, Kenneth D Tew
Nov 22, 2005·Free Radical Research·Sanja Pavlica, Rolf Gebhardt
Oct 3, 2006·Neurobiology of Disease·Richard E HartmanDavid M Holtzman
Aug 24, 2007·European Journal of Pharmacology·Dong Hyun KimJong Hoon Ryu
Jun 2, 2009·Biological & Pharmaceutical Bulletin·Yun Ho Choi, Guang Hai Yan
Nov 3, 2009·Biochemical and Biophysical Research Communications·Ying FengRui-tian Liu
Oct 20, 2010·The British Journal of Nutrition·Jeremy P E Spencer
Sep 17, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ertugrul UzarYasar Altun
Dec 17, 2011·European Journal of Pharmacology·Se Jin ParkJong Hoon Ryu
Mar 27, 2013·European Journal of Pharmacology·Mohammad Taghi MansouriYaghoub Farbood
Apr 23, 2013·European Journal of Pharmacology·Chandrashekaran GirishSadasivam Balakrishnan
Feb 25, 2014·Pharmacology, Biochemistry, and Behavior·Mohammad Taghi MansouriBehnam Ghorbanzadeh

❮ Previous
Next ❯

Citations

May 11, 2017·Nutrients·Dominik SzwajgierKatarzyna Pustelniak
Sep 5, 2017·Nutrients·Francesca Danesi, Lynnette R Ferguson
Feb 9, 2019·Neurological Research·Mehdi GoudarziSaeed Mehrzadi
Aug 12, 2020·Neurochemical Research·Guilherme Lopes DornellesCinthia Melazzo de Andrade
Mar 12, 2021·Advances in Nutrition·Ashutosh GuptaAnupam Bishayee
Jun 2, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Priya SharmaNitin Bansal
Jan 30, 2018·ACS Chemical Neuroscience·Krystyna Skalicka-WozniakAnna Boguszewska-Czubara

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.