Beneficial effects of fenofibrate in pulmonary hypertension in rats

Molecular and Cellular Biochemistry
Palak GalhotraSubir Kumar Maulik

Abstract

Pulmonary hypertension (PH) is a morbid complication of cardiopulmonary as well as several systemic diseases in humans. It is rapidly progressive and fatal if left untreated. In the present study, we investigated the effect of PPARα agonist fenofibrate (FF) on monocrotaline (MCT)-induced PH in rats. FF, because of its pleiotropic property, could be helpful in reducing inflammation, oxidative stress, and reactive oxygen species. On day 1, MCT (50 mg/kg, s.c.) was given to all the rats in MCT, sildenafil, and FF group except normal control rats. After 3 days of giving MCT, sildenafil (175 µg/kg, orally) and FF (120 mg/kg, orally) were given for 25 days. Echocardiography, hemodynamic parameters, fulton's index, histopathology, oxidative stress parameters, inflammatory markers, Bcl2/Bax gene expression ratio in the right ventricle, and protein expression for NOX-1 in lungs were studied in all the groups. FF has shown to prevent decrease in ratio of pulmonary artery acceleration time to ejection time, increase in ratio of right ventricular outflow tract dimension to aortic outflow dimension, rise in right ventricular systolic pressure, right ventricular hypertrophy, increase in the percentage medial wall thickness (%MWT), increase i...Continue Reading

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Citations

Jan 9, 2019·Frontiers in Physiology·Klaus-Dieter SchlüterRainer Schulz
Jun 17, 2021·CPT: Pharmacometrics & Systems Pharmacology·Rui-Sheng Wang, Joseph Loscalzo
Aug 26, 2021·Journal of Experimental Pharmacology·Ronald Zolty

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