Abstract
The aim of the present study was to investigate the effects of GPI 6150, a new poly(ADP-ribose) polymerase (PARP) inhibitor, in the pathogenesis of splanchnic artery occlusion (SAO) shock. SAO shock was induced in rats by clamping both the superior mesenteric artery and the celiac trunk for 45 min, followed by reperfusion. At 60 min after reperfusion, SAO-shocked rats developed a significant fall in mean arterial blood pressure, significant increase of tissue myeloperoxidase activity (111 +/- 4.3 U/100 mg wet tissue vs. 28 +/- 3.2 U/100 mg wet tissue of sham-operated rats), and marked histological injury to the distal ileum and a significant mortality (0% survival at 2 h after reperfusion). Immuno-histochemical examination demonstrated a marked increase in the immunoreactivity to PARP, P-selectin, and intercellular adhesion molecule (ICAM-1) in the necrotic ileum. GPI 6150 treatment significantly improved mean arterial blood pressure, prevented the infiltration of neutrophils (72 +/- 3.6 U/100 mg wet tissue) into the reperfused intestine, improved the histological status of the reperfused tissues, markedly reduced the intensity of P-selectin and ICAM-1 in tissue section from SAO-shocked rats, and improved survival. In conclusio...Continue Reading
References
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Nov 1, 1989·Circulation·R A KlonerP Whittaker
Apr 1, 1986·The Journal of Clinical Investigation·I U SchraufstatterC G Cochrane
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I U SchraufstatterC G Cochrane
Nov 1, 1985·Journal of Pharmacological Methods·K M MullaneB Smith
May 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H Bitterman, A M Lefer
Dec 1, 1973·The Journal of Surgical Research·L B HinshawL J Greenfield
Nov 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K Ikai, K Ueda
Feb 10, 1984·Science·K M Milam, J E Cleaver
Dec 1, 1994·British Journal of Pharmacology·F SquadritoA Saitta
Feb 4, 1994·Science·J ZhangS H Snyder
May 1, 1993·The Journal of Surgical Research·K KoikeA Banerjee
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·A M Lefer, D J Lefer
Aug 1, 1996·Shock·C Szabó
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·C ThiemermannJ R Vane
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·J M de MurciaG de Murcia
Jul 1, 1997·British Journal of Pharmacology·S CuzzocreaC Szabó
Oct 23, 1997·Nature Medicine·M J EliassonV L Dawson
Feb 17, 1998·Cardiovascular Research·B ZingarelliC Szabó
Aug 15, 1998·Trends in Pharmacological Sciences·C Szabó, V L Dawson
Aug 28, 1998·European Journal of Pharmacology·M EndresC Szabó
Feb 19, 1999·Oncogene·S PlazaS Saule
Sep 2, 1999·Critical Care Medicine·S CuzzocreaA P Caputi
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M Simbulan-RosenthalM E Smulson
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P K ChatterjeeC Thiemermann
Jun 24, 2000·British Journal of Pharmacology·M C McDonaldC Thiemermann
Aug 18, 2000·Shock·L LiaudetA L Salzman
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·L LiaudetC Szabo
Nov 30, 2000·Biochemical and Biophysical Research Communications·J ZhangJ H Li
Mar 14, 2001·European Journal of Pharmacology·E MazzonS Cuzzocrea
Citations
Aug 24, 2006·Intensive Care Medicine·Eberhard BarthCsaba Szabó
Feb 5, 2009·Intensive Care Medicine·Ke-Xuan LiuZhengyuan Xia
Jul 31, 2003·Pharmacology & Therapeutics·Ian A Clark, William B Cowden
May 24, 2003·Best Practice & Research. Clinical Gastroenterology·Jeroen J Kolkman, Peter B F Mensink
May 3, 2005·Nature Reviews. Drug Discovery·Prakash Jagtap, Csaba Szabó
Aug 19, 2003·Shock·Salvatore CuzzocreaLidia Sautebin
Jun 5, 2004·Shock·Salvatore CuzzocreaChristoph Thiemermann
Dec 16, 2004·Critical Care Medicine·Gábor SzabóSiegfried Hagl
Dec 17, 2003·Shock·Stefania MarzoccoSalvatore Cuzzocrea
Jan 31, 2004·Shock·Kazunori MurakamiDaniel L Traber
Feb 11, 2004·Shock·Kanneganti G K MurthyCsaba Szabó
Sep 21, 2004·Shock·Salvatore CuzzocreaAchille P Caputi
Oct 26, 2005·Shock·Balázs HauserHubert Schelzig
Jul 20, 2004·Clinical Microbiology Reviews·Ian A ClarkWilliam B Cowden
Sep 13, 2003·British Journal of Pharmacology·Salvatore CuzzocreaChristoph Thiemermann
Jun 6, 2006·Medicinal Research Reviews·Ana OlmosSalvador Máñez
Jul 26, 2006·British Journal of Pharmacology·M HaddadI Margaill
Jun 5, 2004·European Journal of Pharmacology·Rosanna Di PaolaSalvatore Cuzzocrea
Nov 29, 2005·European Journal of Pharmacology·Rosanna Di PaolaSalvatore Cuzzocrea
May 25, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kishor Devalaraja-NarashimhaBabu J Padanilam
Jul 19, 2002·Biochemical Pharmacology·Emanuela MazzonSalvatore Cuzzocrea
Jun 5, 2015·Journal of Veterinary Emergency and Critical Care·Hope F DouglasRalph G Meyer
Feb 24, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Leonardo CavoneAlberto Chiarugi
Oct 30, 2004·Stroke; a Journal of Cerebral Circulation·Eun-Mi ParkCostantino Iadecola
Jan 13, 2005·The Journal of Pharmacology and Experimental Therapeutics·Tiziana GenoveseSalvatore Cuzzocrea
Feb 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Terézia B AndrásiSiegfried Hagl
Mar 26, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Salvatore CuzzocreaZhao-Qi Wang
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra AldinucciAlberto Chiarugi