Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress

Brain Research
Xituan JiZhou Fei

Abstract

Traumatic brain injury (TBI) is a leading cause of mortality and disability among the young population. It has been shown that hydrogen gas (H(2)) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (OH, the most cytotoxic ROS). Recently, we have found that H(2) inhalation significantly improved the survival rate and organ damage of septic mice. In the present study, we investigated the effectiveness of H(2) therapy on brain edema, blood-brain barrier (BBB) breakdown, neurological dysfunction and injury volume in TBI-challenged rats. In addition, we investigated the effects of H(2) treatment on the changes of oxidative products and antioxidant enzymes in brain tissue of TBI-challenged rats. Hydrogen treatment was given by exposure to 2% H(2) from 5 min to 5h after sham or TBI operation, respectively. Here, we found that TBI-challenged rats showed significant brain injuries characterized by the increase of BBB permeability, brain edema and lesion volume as well as neurological dysfunction, which was significantly attenuated by 2% H(2) treatment. In addition, we found that the decrease of oxidative products and the increase of endogenous antioxidant enzymatic activities in the brain tissue may be as...Continue Reading

References

Nov 4, 2000·Journal of Neurotrauma·A LewénP H Chan
Aug 18, 2001·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·H SauerJ Hescheler
Nov 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L LonghiT K McIntosh
Nov 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N MarklundL Hillered
Jun 4, 2002·Journal of Neurotrauma·Raj K NarayanLorraine Yurkewicz
Sep 20, 2006·The Journal of Head Trauma Rehabilitation·Jean A LangloisMarlena M Wald
Aug 4, 2007·Biochemical and Biophysical Research Communications·Kei-ichi FukudaShigeo Ohta
Jan 25, 2008·Critical Care Medicine·Demeral David LiuHsing I Chen
Jun 11, 2008·Biochemical and Biophysical Research Communications·Kentaro HayashidaKeiichi Fukuda
Jul 8, 2008·Neuroscience Letters·Jianmei CaiRunping Li
Aug 19, 2008·Biochemical and Biophysical Research Communications·Yasunori SatoAkihito Ishigami
Jan 27, 2009·Brain Research·Gerald A MatchettJohn H Zhang
Mar 3, 2009·Biochemical and Biophysical Research Communications·Yan-Fei MaoXue-Jun Sun
Apr 9, 2009·Free Radical Research·Xingfeng ZhengHongbin Yuan
Jun 13, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ravindra M SatputeHatim F Daginawala
Nov 3, 2009·The Clinical Neuropsychologist·Thomas W McAllister
Dec 31, 2009·Kidney International·James F George, Anupam Agarwal

❮ Previous
Next ❯

Citations

Mar 6, 2012·Acta Pharmacologica Sinica·Juan QuJian-hua Qiu
Jan 22, 2011·Clinical and Experimental Pharmacology & Physiology·Xing-Feng ZhengZhao-Fan Xia
May 18, 2013·Medical Gas Research·Brandon J DixonJohn H Zhang
Jun 22, 2012·Oxidative Medicine and Cellular Longevity·Kinji OhnoMasafumi Ito
Nov 8, 2011·International Journal of Pediatric Otorhinolaryngology·Juan QuJianhua Qiu
May 16, 2014·BioMed Research International·Keliang XieGuolin Wang
Jan 21, 2014·Progress in Neurobiology·Jiao DengLize Xiong
Apr 2, 2014·BioMed Research International·André Mendes ArentAlcir Luiz Dafre
Nov 9, 2016·Medical Gas Research·Cheng-Lin LiuGang Chen
Jun 15, 2012·The Journal of Trauma and Acute Care Surgery·Joao B Rezende-Neto
Jun 26, 2018·Frontiers in Neuroscience·Xiaoru CheSheng Chen
Mar 22, 2014·Molecular and Cellular Biochemistry·Hai-Guang XinXiao-Hui Miao
Nov 7, 2020·Hormone Molecular Biology and Clinical Investigation·Daniele Suzete Persike, Suad Yousif Al-Kass
May 5, 2021·Journal of Neurotrauma·Samuel S ShinTodd J Kilbaugh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.